Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 451-460 of 2,298 results
Rheumatology Advances in Practice, 2023 • November 20, 2023
This review discusses the efficacy of stem cell therapy (SCT) using mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) for systemic sclerosis (SSc). Both MSCT and HSCT could improve dis...
KEY FINDING: Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) improve disease activity and severity in SSc patients.
Neural Regeneration Research, 2024 • September 22, 2023
This review discusses the combination of stem cells (SCs) and 3D bioprinting scaffolds for the repair of spinal cord injury (SCI). It covers the mechanisms of stem cell therapy, different types of ste...
KEY FINDING: Stem cell therapy has the potential to repair damaged tissue in the spinal cord and promote the restoration of normal functionality in the nervous system due to their regenerative properties.
Stem Cell Research & Therapy, 2023 • December 20, 2023
This study explored the effects of combining human iPSC-derived sNPC transplantation with tail nerve electrical stimulation (TANES) on chronic spinal cord injury (SCI) in rats. The results indicated t...
KEY FINDING: TANES promoted a significantly higher number of sNPCs migrating away from the site of injection and influenced long-distance axonal/dendritic projections, especially in the rostral direction.
Stem Cell Research & Therapy, 2024 • January 1, 2024
SCI repair remains a challenge for the medical field. Exosomes derived from various cells are important intercellular communication substances that can mediate SCI repair by inhibiting inflammatory re...
KEY FINDING: NSCs-Exos promoted neural regeneration by regulating miR-219a-2-3p to repair the SCI.
Theranostics, 2024 • January 1, 2024
This study investigates the underlying mechanisms of MSC-mediated SCI repair using HA-MSC scaffolds and reveals the dominant role of IL-10 in MSC treatment for spinal cord repair. The research demonst...
KEY FINDING: HA scaffolds improve MSC survival and inhibit neuroinflammation after SCI, as evidenced by decreased pro-inflammatory cytokines and increased anti-inflammatory cytokines.
Heliyon, 2024 • November 25, 2023
The study demonstrates that transplanting iP-A2B5+OPCs can improve neurological function recovery after spinal cord contusion in rats. This improvement is potentially linked to changes in the expressi...
KEY FINDING: iP-A2B5+OPCs transplantation improved the neurobehavioural performance of rats with spinal cord contusion.
International Journal of Stem Cells, 2024 • January 8, 2024
The review investigates the potential of ERCs as promising candidates for treating neurological disorders, emphasizing their accessibility and high survival rates after transplantation. ERCs have show...
KEY FINDING: ERCs can differentiate into dopamine-producing neurons, making them potentially useful for treating Parkinson's disease.
Journal of Tissue Engineering, 2024 • January 1, 2024
This study investigates the potential of XIST-overexpressing BMSCs to treat spinal cord injury (SCI) by modulating macrophage polarization and improving the neural stem cell (NSC) microenvironment. Th...
KEY FINDING: XIST overexpression in BMSCs promotes M2 macrophage polarization, suppressing inflammation in the SCI microenvironment.
Cells, 2024 • January 17, 2024
The study investigated the efficacy of mechanically activated human lipoaspirate transplantation on sensorimotor recovery after acute spinal cord contusion in rats. Results indicated that activated fa...
KEY FINDING: Activated fat transplantation reduced endogenous inflammation post-SCI by decreasing the levels of pro-inflammatory cytokines (IL-6 and TNF-α).
Stem Cell Research & Therapy, 2024 • January 23, 2024
This study aimed to assess the efficacy of early SVF transplantation in improving sensorimotor recovery following acute thoracic spinal cord contusion in rats. The results indicated that subdural inje...
KEY FINDING: SVF injection reduced inflammation at the site of the spinal cord injury two weeks after the initial injury.