Regenerative Medicine Research

KEY FINDING: Combined MSC and NSC transplantation reduced fibrosis formation and inflammation levels in the injured spinal cord.

KEY FINDING: The bright-ferritin mechanism allows for high-resolution, specific, and on-demand longitudinal tracking of hNPCs grafts in the rat spinal cord.

KEY FINDING: The level of serum albumin in the animals that received IDO1-EVs was increased compared to the SCI group, suggesting a reduction in hypoalbuminemia.

KEY FINDING: MSC-Exo can effectively suppress inflammatory responses and oxidative stress following SCI, contributing to neuronal survival.

KEY FINDING: Transplantation of neural progenitor cells (NPCs) can lead to nervous system recovery through mechanisms like remyelination, axonal regeneration, tissue sparing, angiogenesis, and release of neurotrophic factors.

KEY FINDING: The review of 43 studies showed that MSC transplantation is generally considered safe and tolerable, with the most common adverse events being mild, such as fever, headache, or pain at the injection site.

KEY FINDING: Both natural and synthetic scaffold-driven cell transplantation are superior to the control group in treating SCI rats, with statistically significant differences.

KEY FINDING: MSC-based therapies have shown promising results in pathologies like spinal cord injuries, wounds, and skin and eye diseases.

KEY FINDING: MSC and HSC therapies can improve disease activity and severity in organs affected by SLE, such as the kidney, lung, liver, and bone.

KEY FINDING: DPSCs can differentiate into neuron-like cells, potentially replacing damaged neurons in SCI.