Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 171-180 of 2,298 results
Tissue Engineering, 2014 • May 1, 2014
This study investigates the long-term effects of implanted multiple channel bridges on axon regeneration and matrix changes in a rat spinal cord injury model. The bridges are designed to provide struc...
KEY FINDING: Axons grew into and through the channels of the implanted bridges, with axon density increasing over time and peaking at 6 months post-implantation, even after the bridge had fully degraded.
World J Stem Cells, 2013 • October 26, 2013
Pluripotent stem cells are hoped to be donor cells in transplantation in regenerative medicine. Somatic stem cells with the ability to differentiate in various species of cells have been used as donor...
KEY FINDING: Ectodermal stem cells and mesodermal (mesenchymal) stem cells potentially differentiate to neurons, while it seems that endodermal stem cells do not differentiate to neurons without dedifferentiation or induction to iPS cells.
BioMed Research International, 2013 • August 7, 2013
This review discusses the supportive roles of various ECM molecules in neurite outgrowth, while acknowledging that ECM molecules also impact synapse formation and neural stem cell migration. Novel dev...
KEY FINDING: Laminins promote axonal growth in both the developing and adult nervous systems, particularly in areas where regeneration occurs.
BMC Neuroscience, 2013 • November 13, 2013
This study investigates the differential properties of canine olfactory ensheathing cells (OECs) from the olfactory bulb (OB-OECs) and mucosa (OM-OECs) compared to Schwann cells, focusing on their mig...
KEY FINDING: OB-OECs migrate significantly faster than OM-OECs and Schwann cells in a scratch wound assay.
Curr Opin Organ Transplant, 2013 • December 1, 2013
Schwann cell transplantation for spinal cord injury is in the early stages of clinical testing, following promising preclinical development. The FDA approved a Phase 1 safety and feasibility study bas...
KEY FINDING: Transplanted Schwann cells have shown reparative effects in the damaged spinal cord, supporting axonal sprouting and myelination.
Nature Communications, 2013 • November 12, 2013
This study investigates the role of chondroitin sulfate N-acetylgalactosaminyltransferase-1 (T1) in spinal cord injury recovery. The research demonstrates that T1 knockout mice exhibit superior recove...
KEY FINDING: T1KO mice exhibit significantly better recovery from spinal cord injury compared to wild-type and ChABC-treated mice, based on locomotor behaviors and histological analysis.
PLoS ONE, 2013 • November 1, 2013
The study investigates the role of GFAP and vimentin in nerve regeneration and synaptic stripping after sciatic nerve lesion in mice. Results showed reduced synaptic elimination, delayed reinnervation...
KEY FINDING: GFAP–/–Vim–/– mice showed less removal of synaptic boutons from injured motoneurons compared to wild-type mice after axotomy.
Pain, 2014 • March 1, 2014
This study investigates the effect of systemic artemin administration on nerve regeneration and functional recovery in rats following different types of nerve injuries. The results showed that artemin...
KEY FINDING: Artemin transiently reversed tactile and thermal hypersensitivity following axotomy, ligation or crush injury.
Journal of Otolaryngology - Head and Neck Surgery, 2013 • December 19, 2013
The study investigates the combinatorial effect of neural precursor cells (NPCs) and self-assembling peptides (SAPs) on nerve regeneration after spinal cord injury in rats. Results showed that SAP + N...
KEY FINDING: SAP + NPC transplantation significantly improved locomotor score compared to control groups.
J. Cell. Mol. Med., 2014 • February 1, 2014
The study investigates the cytoprotective effects of 17b-estradiol (E2) on human eyelid adipose-derived stem cells (hEASCs) against oxidative stress induced by hydrogen peroxide (H2O2) in vitro and in...
KEY FINDING: E2 protects hEASCs against H2O2-induced cell death in vitro.