Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 181-190 of 2,298 results
JOURNAL OF NEUROTRAUMA, 2014 • May 1, 2014
This study investigates the effects of ChABC treatment on astrogliosis and revascularization after spinal cord injury (SCI) in rats. The researchers injected ChABC intrathecally after a spinal cord he...
KEY FINDING: ChABC treatment effectively cleaves CSPG glycosaminoglycan chains and stimulates axonal remodeling within the injury site, accompanied by an extended period of astrocyte remodeling.
Journal of Clinical and Diagnostic Research, 2013 • November 10, 2013
This study focused on isolating Globose Basal Cells (GBCs) from the olfactory mucosa of Albino Wistar rats, as these cells possess the ability to regenerate olfactory mucosa throughout life. The chall...
KEY FINDING: The study standardized techniques for isolating GBCs from rat olfactory mucosa using GBC-III antibody and FACS.
PLoS ONE, 2014 • January 20, 2014
This study utilizes a high-density microarray to profile the temporal transcriptome dynamics during spinal cord regeneration in zebrafish, identifying 3842 differentially expressed genes. Cluster anal...
KEY FINDING: A total of 3842 genes were found to be differentially expressed during spinal cord regeneration, with maximum numbers of genes differentially expressed at 7 days post injury.
STEM CELLS TRANSLATIONAL MEDICINE, 2014 • February 3, 2014
This study assessed the safety and efficacy of transplanting bone marrow nucleated cells (BMNCs) to treat children with complete interruption of spinal cord (SC) continuity. The results indicate that ...
KEY FINDING: BMNC transplantation in children with complete SC injury is safe and feasible.
PLoS ONE, 2014 • February 3, 2014
This study introduces the use of self-complementary adeno-associated virus serotype 2 (scAAV2) as an effective tracer for labeling axons, demonstrating its ability to efficiently transduce neurons and...
KEY FINDING: scAAV2-GFP efficiently transduces neurons in the sensorimotor cortex, red nucleus, and DRG, with strong GFP expression transported anterogradely along axons to label numerous axon fibers from CST, RST, and central axons of DRG.
Journal of Anatomy, 2014 • February 7, 2014
This study examined the role of c-Jun activation in neonatal rat motoneurons after nerve crush injury, observing both degeneration and regeneration. The key finding was that all injured motoneurons in...
KEY FINDING: Nerve crush injury in neonatal rats leads to two distinct outcomes for motoneurons: approximately 60% undergo degeneration, while 40% survive and regenerate.
Mol Cell Neurosci, 2014 • March 1, 2014
This study demonstrates that JUN can promote axon growth and regeneration in cortical neurons, and suggests that it does so in a way that is mechanistically distinct from what is observed in periphera...
KEY FINDING: The Jun oncogene/signal transducer and activator of transcription 6 (JUN/STAT6) combination increased neurite growth in dissociated cortical neurons and in injured cortical slices.
The Journal of Neuroscience, 2014 • February 12, 2014
This study identifies periostin (POSTN) as a key factor secreted by GDAsBMP astrocytes that promotes axonal regeneration after spinal cord injury (SCI). POSTN expression in GDAsBMP is essential for th...
KEY FINDING: Periostin (POSTN) is identified as a key component of GDABMP-induced axonal regeneration.
PLoS ONE, 2014 • February 11, 2014
This study investigates the expression of guidance and synaptogenic molecules in the cervical spinal cord of mice, both healthy and with spinal cord injuries, focusing on interneuron populations. The ...
KEY FINDING: Most of the guidance and synaptogenic molecules studied are present not only in the developing CNS but also in the adult CNS.
BMC Developmental Biology, 2014 • February 16, 2014
The study introduces electroablation, a novel method for inducing localized tissue injury using a microelectrode to deliver electrical pulses. This technique is demonstrated in zebrafish larvae and ad...
KEY FINDING: Electroablation can be used for precise neurectomy in peripheral nerves and the spinal cord of zebrafish larvae, allowing the study of nerve degeneration and regeneration.