Schwann cell-free adult canine olfactory ensheathing cell preparations from olfactory bulb and mucosa display differential migratory and neurite growth-promoting properties in vitro

BMC Neuroscience, 2013 · DOI: 10.1186/1471-2202-14-141 · Published: November 13, 2013

Regenerative Medicine Neurology Genetics

Simple Explanation

This study investigates the potential of olfactory ensheathing cells (OECs) and Schwann cells to promote axonal growth and remyelination after spinal cord injury. The research compares OECs from the olfactory bulb (OB-OECs) and mucosa (OM-OECs) in dogs, focusing on their migration, phagocytosis, and impact on neurite growth in lab settings. The study found that OB-OECs migrate faster and enhance neurite growth of human model neurons more effectively than Schwann cells, indicating distinct properties of these cell types.

Study Duration

Not specified

Participants

Canine olfactory ensheathing cells (OECs) and Schwann cells

Evidence Level

In vitro study

Key Findings

1
OB-OECs migrate significantly faster than OM-OECs and Schwann cells in a scratch wound assay.
2
Activating protein kinase C enhances the motility of ensheathing cells from both the olfactory bulb and mucosa, but Schwann cells are less responsive.
3
OB-OECs promote greater neurite outgrowth of developing human neurons compared to OM-OECs and Schwann cells.

Research Summary

This study investigates the differential properties of canine olfactory ensheathing cells (OECs) from the olfactory bulb (OB-OECs) and mucosa (OM-OECs) compared to Schwann cells, focusing on their migratory and neurite growth-promoting capabilities in vitro. The key findings reveal that OB-OECs exhibit superior migration rates and neurite growth enhancement of human model neurons, highlighting distinct characteristics among these glial cell types. The research also demonstrates that activating the protein kinase C pathway enhances the migration of OECs from the olfactory bulb, indicating potential targets for therapeutic intervention.

Practical Implications

Therapeutic potential

OEC and Schwann cell transplantation may create a regenerative environment in the central nervous system.

Cell-specific therapies

Distinct properties of OB-OECs suggest their potential for targeted therapies.

Drug development

The protein kinase C pathway may be a target for enhancing OEC migration.

Study Limitations

1
In vitro study
2
Short migration time in scratch wound assay
3
Study focused on canine cells and human model neurons

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