Journal of Otolaryngology - Head and Neck Surgery, 2013 · DOI: 10.1186/1916-0216-42-60 · Published: December 19, 2013
Cranial nerve injury can cause loss of neural cells and support matrix, leading to impairment. The study explores using neural precursor cells (NPCs) and self-assembling peptides (SAPs) to promote nerve regeneration. SAPs can form a scaffold that helps link damaged nerve segments. NPCs can replace lost cells and enhance myelination, which is important for nerve function. The study found that combining SAPs and NPCs improved nerve function and survival in rats with spinal cord injury, suggesting this approach could help with nerve repair and regeneration.
The combined use of SAPs and NPCs may offer a therapeutic strategy for treating nerve injuries by providing structural support and cellular replacement.
Given the similarities between the PNS and CNS, the therapeutic strategies employed in this study could potentially be applicable in peripheral nerve regeneration.
The study demonstrated improved nerve conduction velocity and enhanced functional recovery, suggesting the combined treatment can lead to better neurological outcomes.