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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Regenerative Medicine Research

Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.

Showing 161-170 of 2,298 results

Spinal Cord InjuryRegenerative MedicineNeurology

A Neonatal Mouse Spinal Cord Injury Model for Assessing Post-Injury Adaptive Plasticity and Human Stem Cell Integration

PLoS ONE, 2013 • August 19, 2013

The study developed a neonatal mouse spinal cord compression (SCC) injury model to investigate adaptive plasticity and human stem cell integration after injury. The model allows for high-throughput as...

KEY FINDING: Dramatic degeneration of axons and synaptic contacts was evident within 24 hours of SCC, and loss of neurons in the injured segment was evident for at least a month thereafter.

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Spinal Cord InjuryRegenerative MedicineNeurology

Conditioned Medium from Bone Marrow-Derived Mesenchymal Stem Cells Improves Recovery after Spinal Cord Injury in Rats: An Original Strategy to Avoid Cell Transplantation

PLoS ONE, 2013 • August 1, 2013

This study investigates the therapeutic potential of BMSC-conditioned medium (CM) in a rat model of spinal cord injury (SCI), focusing on its effects on secondary injury processes. In vitro experiment...

KEY FINDING: BMSC-conditioned medium (BMSC-CM) protects neurons from apoptosis in vitro, suggesting a neuroprotective effect.

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Regenerative MedicineGenetics

Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl

Stem Cell Reports, 2013 • June 4, 2013

This study introduces a comprehensive set of germline transgenic strains in the laboratory-bred salamander Ambystoma mexicanum (axolotl) that open up the cellular and molecular genetic dissection of r...

KEY FINDING: The study successfully established germline transgenic axolotl strains showing faithful, cell-type-specific expression of EGFP gene using tissue-specific promoters from different animal species.

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Spinal Cord InjuryRegenerative MedicineNeurology

Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury

The Journal of Neuroscience, 2013 • September 25, 2013

This study demonstrates that suppressing PTEN expression with shRNA promotes the regeneration of injured CST axons after SCI. The regenerating axons form anatomical synapses and interact with the extr...

KEY FINDING: Suppression of PTEN expression using shRNA promotes regeneration of injured corticospinal tract (CST) axons after spinal cord injury (SCI).

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Spinal Cord InjuryRegenerative MedicineNeurology

Tissue sparing, behavioral recovery, supraspinal axonal sparing/regeneration following sub-acute glial transplantation in a model of spinal cord contusion

BMC Neuroscience, 2013 • September 27, 2013

The study demonstrates that transplanting OEG and SCs in the sub-acute phase after spinal cord injury improves anatomical outcomes. This is achieved by increasing spared/regenerated supraspinal fibers...

KEY FINDING: Both OEG and SCs transplantation increased locomotion in rats with spinal cord injuries, as measured by open field tests.

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Spinal Cord InjuryRegenerative Medicine

Bridging defects in chronic spinal cord injury using peripheral nerve grafts combined with a chitosan-laminin scaffold and enhancing regeneration through them by co-transplantation with bone-marrow-derived mesenchymal stem cells: Case series of 14 patients

The Journal of Spinal Cord Medicine, 2014 • January 1, 2014

This study investigated the effect of bridging defects in chronic spinal cord injury using peripheral nerve grafts combined with a chitosan-laminin scaffold and enhancing regeneration through them by ...

KEY FINDING: Motor level improved four levels in 2 cases and two levels in 12 cases.

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Spinal Cord InjuryRegenerative MedicineNeurology

Gene Expression Changes in the Injured Spinal Cord Following Transplantation of Mesenchymal Stem Cells or Olfactory Ensheathing Cells

PLoS ONE, 2013 • October 11, 2013

This study analyzed gene expression changes in the spinal cord after injury and transplantation of MSCs or OECs. Acute transplantation of MSCs and OECs induced early expression of genes related to cel...

KEY FINDING: MSC and OEC transplanted acutely after injury up-regulate genes related to tissue protection and regeneration.

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UrologyRegenerative Medicine

Stem Cell Therapy in Bladder Dysfunction: Where Are We? And Where Do We Have to Go?

BioMed Research International, 2013 • August 7, 2013

This review discusses the current status of stem cell therapy for bladder dysfunction, focusing on experimental studies using various stem cell types like ADSCs, BMSCs, and SkMSCs. The mechanisms of s...

KEY FINDING: MSCs augment healing through cell replacement, stimulation of cell proliferation, and angiogenesis, although data on bladder dysfunction repair is scarce compared to other tissues.

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Spinal Cord InjuryRegenerative MedicineNeurology

Permissive Schwann Cell Graft/Spinal Cord Interfaces for Axon Regeneration

Cell Transplant, 2015 • January 1, 2015

This study demonstrates that the transplantation of a SC bridge alone promotes brainstem axon regeneration. This study demonstrated that initially fluid bridges promote both a robust increase in the e...

KEY FINDING: Initially fluid bridges of SCs and Matrigel improved regeneration of brainstem axons across the rostral interface compared to pregelled bridges.

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Spinal Cord InjuryCardiovascular ScienceRegenerative Medicine

Partial Restoration of Cardiovascular Function by Embryonic Neural Stem Cell Grafts after Complete Spinal Cord Transection

The Journal of Neuroscience, 2013 • October 23, 2013

This study investigates the potential of embryonic neural stem cell grafts to restore cardiovascular function after complete spinal cord transection in adult rats. The key finding is that brainstem-de...

KEY FINDING: Grafting brainstem-derived neural stem cells (BS-NSCs) resulted in recovery of basal cardiovascular parameters in rats with complete spinal cord transection.

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