Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 161-170 of 2,298 results
PLoS ONE, 2013 • August 19, 2013
The study developed a neonatal mouse spinal cord compression (SCC) injury model to investigate adaptive plasticity and human stem cell integration after injury. The model allows for high-throughput as...
KEY FINDING: Dramatic degeneration of axons and synaptic contacts was evident within 24 hours of SCC, and loss of neurons in the injured segment was evident for at least a month thereafter.
PLoS ONE, 2013 • August 1, 2013
This study investigates the therapeutic potential of BMSC-conditioned medium (CM) in a rat model of spinal cord injury (SCI), focusing on its effects on secondary injury processes. In vitro experiment...
KEY FINDING: BMSC-conditioned medium (BMSC-CM) protects neurons from apoptosis in vitro, suggesting a neuroprotective effect.
Stem Cell Reports, 2013 • June 4, 2013
This study introduces a comprehensive set of germline transgenic strains in the laboratory-bred salamander Ambystoma mexicanum (axolotl) that open up the cellular and molecular genetic dissection of r...
KEY FINDING: The study successfully established germline transgenic axolotl strains showing faithful, cell-type-specific expression of EGFP gene using tissue-specific promoters from different animal species.
The Journal of Neuroscience, 2013 • September 25, 2013
This study demonstrates that suppressing PTEN expression with shRNA promotes the regeneration of injured CST axons after SCI. The regenerating axons form anatomical synapses and interact with the extr...
KEY FINDING: Suppression of PTEN expression using shRNA promotes regeneration of injured corticospinal tract (CST) axons after spinal cord injury (SCI).
BMC Neuroscience, 2013 • September 27, 2013
The study demonstrates that transplanting OEG and SCs in the sub-acute phase after spinal cord injury improves anatomical outcomes. This is achieved by increasing spared/regenerated supraspinal fibers...
KEY FINDING: Both OEG and SCs transplantation increased locomotion in rats with spinal cord injuries, as measured by open field tests.
The Journal of Spinal Cord Medicine, 2014 • January 1, 2014
This study investigated the effect of bridging defects in chronic spinal cord injury using peripheral nerve grafts combined with a chitosan-laminin scaffold and enhancing regeneration through them by ...
KEY FINDING: Motor level improved four levels in 2 cases and two levels in 12 cases.
PLoS ONE, 2013 • October 11, 2013
This study analyzed gene expression changes in the spinal cord after injury and transplantation of MSCs or OECs. Acute transplantation of MSCs and OECs induced early expression of genes related to cel...
KEY FINDING: MSC and OEC transplanted acutely after injury up-regulate genes related to tissue protection and regeneration.
BioMed Research International, 2013 • August 7, 2013
This review discusses the current status of stem cell therapy for bladder dysfunction, focusing on experimental studies using various stem cell types like ADSCs, BMSCs, and SkMSCs. The mechanisms of s...
KEY FINDING: MSCs augment healing through cell replacement, stimulation of cell proliferation, and angiogenesis, although data on bladder dysfunction repair is scarce compared to other tissues.
Cell Transplant, 2015 • January 1, 2015
This study demonstrates that the transplantation of a SC bridge alone promotes brainstem axon regeneration. This study demonstrated that initially fluid bridges promote both a robust increase in the e...
KEY FINDING: Initially fluid bridges of SCs and Matrigel improved regeneration of brainstem axons across the rostral interface compared to pregelled bridges.
The Journal of Neuroscience, 2013 • October 23, 2013
This study investigates the potential of embryonic neural stem cell grafts to restore cardiovascular function after complete spinal cord transection in adult rats. The key finding is that brainstem-de...
KEY FINDING: Grafting brainstem-derived neural stem cells (BS-NSCs) resulted in recovery of basal cardiovascular parameters in rats with complete spinal cord transection.