Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,771-1,780 of 2,298 results
BioMed Research International, 2018 • April 1, 2018
Biomaterial scaffolds show great potential in CNS regeneration by providing tissue repair and functional recovery. They are applied predominantly as hydrogels and biodegradable scaffolds. Biomaterial ...
KEY FINDING: Biomaterial scaffolds can mimic the native extracellular matrix (ECM), providing specific microenvironmental cues to enhance cell survival, infiltration, and differentiation in CNS regeneration.
中国修复重建外科杂志, 2017 • March 1, 2017
This study aimed to explore the impact of short-term low-frequency electrical stimulation (SLES) on the regenerative capabilities of chronic peripheral nerve defects. The study found that SLES can pro...
KEY FINDING: SLES upregulates GAP-43 and BDNF expression in motor and sensory neurons faster than the control group in the early stages after nerve repair.
Cell Transplantation, 2018 • June 1, 2018
OEC transplantation is a promising therapy for SCI, but outcomes vary. The purity and phenotype of transplanted cells differ between studies. Neurotrophins can stimulate favorable behaviors in OECs li...
KEY FINDING: Neurotrophins can improve the quality, purity, and resilience of OECs before transplantation, addressing variability in outcomes.
Cell Transplantation, 2018 • June 1, 2018
OECs have shown promise in treating spinal cord injuries due to their axon growth-promoting properties, but results from transplantation studies have been inconsistent. Variations in OEC purity, the s...
KEY FINDING: Inconsistent outcomes in OEC transplantation studies may be due to the varied purity of cell preparations prior to transplantation.
Cell Transplantation, 2018 • June 1, 2018
This study investigates the transplantation of NeuroRegen scaffolds with human umbilical cord mesenchymal stem cells (MSCs) into two acute complete SCI patients. The patients were diagnosed as complet...
KEY FINDING: The sensory level expanded below the injury level in both patients, and they regained sense function in bowel and bladder.
Cell Transplantation, 2018 • June 1, 2018
Spinal cord injury (SCI) is a heavy burden on patient physiology and psychology. According to our previous work and the advancements in SCI research, ‘microenvironment imbalance’ is the main cause of ...
KEY FINDING: Microenvironment imbalance is defined as an increase in inhibitory factors and decrease in promoting factors for tissues, cells and molecules at different times and spaces.
International Journal of Molecular Sciences, 2018 • June 5, 2018
This study compares the effects of IGF-1 and BMP-7 on osteogenic differentiation of human mesenchymal stem cells (MSCs) from reaming debris (RMSC) and iliac crest bone marrow (BMSC) in vitro. The resu...
KEY FINDING: BMSC showed a more sensitive reaction towards stimulation with IGF-1, leading to a significantly higher degree of osteogenic differentiation compared to stimulation with BMP-7.
Frontiers in Neuroscience, 2018 • May 23, 2018
This study investigates the potential of resveratrol to promote nerve regeneration and motor repair in a rat model of sciatic nerve crush injury. Resveratrol treatment was administered daily for 10 da...
KEY FINDING: Daily resveratrol treatment alleviated motor deficits caused by sciatic nerve crush injury in rats within 10 days, suggesting rapid motor repair.
Biomaterials, 2019 • April 1, 2019
This review comprehensively reports technologies related to ex vivo models and lab-on-a-chip devices used to model regeneration in the peripheral and central nervous systems. It discusses the necessit...
KEY FINDING: Animal models often fail in clinical trials due to differences in healing mechanisms, injury replicability, and biological mismatches between humans and animals.
Front. Mol. Neurosci., 2018 • May 24, 2018
This study investigated the role of CHL1 in peripheral nerve regeneration using a mouse model of femoral nerve injury. CHL1-deficient mice were compared to wild-type mice regarding motor function, axo...
KEY FINDING: CHL1-deficient mice showed decreased preferential motor re-innervation, indicating reduced precision in motor axon targeting after nerve injury.