Significant Improvement of Acute Complete Spinal Cord Injury Patients Diagnosed by a Combined Criteria Implanted with NeuroRegen Scaffolds and Mesenchymal Stem Cells

This study explores a new treatment for complete spinal cord injuries (SCI) using collagen scaffolds, called NeuroRegen scaffolds, combined with human umbilical cord mesenchymal stem cells (MSCs). These scaffolds were implanted into the injury site of two patients diagnosed with acute complete SCI. The researchers used a strict method to diagnose the patients as having complete SCI, combining the American Spinal Injury Association (ASIA) Impairment Scale, MRI scans, and nerve electrophysiology. This is important because it helps ensure that the patients truly had complete injuries before treatment. After one year, the patients showed improvements in both sensory and motor functions. One patient could walk with assistance, and the other regained some leg movement. The study suggests this combined approach could be a promising treatment for acute complete SCI.

• 1
  The sensory level expanded below the injury level in both patients, and they regained sense function in bowel and bladder.
• 2
  The thoracic SCI patient could walk voluntarily with the hip under the help of brace.
• 3
  The cervical SCI patient could raise his lower legs against the gravity in the wheelchair and shake his toes under control.