Regenerative Medicine Research

KEY FINDING: PDRN treatment significantly improved motor function in mice with SCI, as measured by the Basso mouse scale (BMS). The improvement was negated by the co-administration of DMPX, an adenosine receptor antagonist.

KEY FINDING: Long-distance regeneration of motor axons, such as CST axons, across the injury gap in complete spinal cord injury is not well-supported by objective evidence.

KEY FINDING: RXRα protein levels decrease during tail and spinal cord regeneration in adult newts, while RXRα mRNA levels increase.

KEY FINDING: Local injection of BMP7 increased BBB scores in rats with SCI at 1, 2, 4, and 8 weeks post-operation, indicating improved motor function.

KEY FINDING: HDAC inhibitors (HDACi) can promote neurite extension and growth cone remodeling by increasing acetylation of H3 at K9/14, requiring transcription.

KEY FINDING: GABA and baclofen treatments significantly reduced caspase activation in descending neurons 2 weeks after a complete SCI.

KEY FINDING: OPN enhances the directed migration of neuroblasts in the healthy brain, as visualized by BLI, with maximal BLI signal observed at a significantly greater distance to the midline than under control conditions.

KEY FINDING: TexasPEG treatment significantly improved locomotor function recovery in rats compared to the control group, as measured by BBB scores over 5 weeks.

KEY FINDING: Rats treated with BMSCs and TIIA showed significantly higher locomotor scores compared to other groups.

KEY FINDING: Suppression of AMIGO3 combined with NT3 overexpression, induced DRGN to grow neurites on a CME substrate in vitro.