Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,761-1,770 of 2,298 results
Stem Cell Research & Therapy, 2018 • May 11, 2018
This study demonstrated that repeated intravenous injections of hUCB-MSCs can promote functional recovery in rabbits with subacute spinal cord compression injury of two noncontinuous segments. The rec...
KEY FINDING: Repeated injections of hUCB-MSCs at 3-day intervals (3RI) resulted in significantly better functional recovery compared to single injection (SI) or repeated injections at 7-day intervals (7RI).
The Journal of Neuroscience, 2018 • June 6, 2018
This study investigates the mechanisms by which modulation of RPTP sigma promotes axon outgrowth in the presence of inhibitory CSPGs. The findings demonstrate that ISP modulation of RPTP sigma enhance...
KEY FINDING: ISP treatment enhances the degradation of GAG-CSPGs in vitro, leading to increased axon outgrowth.
SMALL GTPASES, 2020 • January 1, 2020
Adult CNS axons fail to regenerate after injury due to extrinsic inhibitory factors and a low intrinsic capacity for axon growth, unlike developing neurons. ARF6 and Rab11, small GTPases, regulate pol...
KEY FINDING: ARF6 activation prevents the axonal transport of integrins in Rab11 endosomes in mature CNS axons, restricting them to the somato-dendritic domain.
Stem Cells International, 2018 • March 27, 2018
This study explores a novel approach to spinal cord injury (SCI) treatment using a combination of dental pulp stem cells (DPSCs), basic fibroblast growth factor (bFGF), and a heparin-poloxamer (HP) hy...
KEY FINDING: Transplanted HP hydrogel containing DPSCs and bFGF had a significant impact on spinal cord repair and regeneration.
Molecular Pain, 2018 • April 10, 2018
This study investigated the effects of blocking TRPV1 with AMG-517 on nerve regeneration after sciatic nerve injury in rats. The results showed that AMG-517 promoted axonal regeneration, decreased gli...
KEY FINDING: Blockage of TRPV1 with AMG-517 markedly promoted axonal regeneration, especially at two weeks after sciatic injury.
International Journal of Molecular Sciences, 2018 • May 17, 2018
This study investigates the dose-dependent effect of human Wharton’s jelly-derived mesenchymal stem cells (hWJ-MSCs) on spinal cord injury (SCI) recovery in rats, comparing single and repeated intrath...
KEY FINDING: Functional recovery of hind limb motion in treated rats was partially dependent on the number of applied cells; higher doses showed better results in BBB testing.
eNeuro, 2018 • May 7, 2018
This study examined the role of Sema3A signaling in motor axon reinnervation of the adult NMJ using a nerve crush model and inducible knockout mice. The researchers found that Sema3A and Npn1 mRNA lev...
KEY FINDING: Sema3A and Npn1 mRNA levels decrease in response to denervation, contrary to previous findings that reported an upregulation of Sema3A after nerve crush injury.
Molecular Therapy, 2018 • July 1, 2018
The study investigates the effect of localized immunomodulation using lentiviral delivery of IL-10 and IL-4 from a multichannel PLG bridge on nerve regeneration after spinal cord injury. The hypothesi...
KEY FINDING: Induced IL-10 and IL-4 expression decreased expression of pro-inflammatory genes and increased pro-regenerative genes relative to control. The anti-inflammatory factors led to increased numbers of axons and myelination.
Sci Transl Med, 2018 • May 23, 2018
This study challenges the conventional understanding of myelin's role in nerve regeneration after spinal cord injury (SCI). The findings demonstrate that adult rat myelin unexpectedly enhances axonal ...
KEY FINDING: Adult rat myelin stimulated the growth of axons emerging from rat neural progenitor cells (NPCs) transplanted into sites of SCI in adult rat recipients.
Chinese Journal of Reparative and Reconstructive Surgery, 2017 • January 1, 2017
This study aimed to observe changes in endogenous Spastin protein expression during the regeneration process after sciatic nerve injury in rats. The results showed that Spastin protein and gene expres...
KEY FINDING: Spastin mRNA and protein expression levels decreased initially after sciatic nerve injury, reaching a minimum at 7 days, and then gradually increased to initial levels by 28 days.