Enhancing the Therapeutic Potential of Olfactory Ensheathing Cells in Spinal Cord Repair Using Neurotrophins

Autologous olfactory ensheathing cell (OEC) transplantation shows promise for spinal cord injury. However, its effectiveness varies due to differences in the cells used across studies. These cells can be influenced by neurotrophic factors. OEC transplantation involves cell preparation, administration, and continuous support. Each phase requires different OEC behaviors, such as rapid expansion during preparation and survival at the injury site after administration. Neurotrophins can optimize OEC behavior in each phase. They can promote cell expansion before transplantation, support survival during transplantation, and enhance integration at the injury site long-term.

• 1
  Neurotrophins can improve the quality, purity, and resilience of OECs before transplantation, addressing variability in outcomes.
• 2
  Coadministration of neurotrophins during transplantation can protect cells, promote cell-cell interactions, and enhance integration at the injury site.
• 3
  Post-transplantation neurotrophin treatment can support the SCI environment by promoting neurogenesis, transplant integration, and angiogenesis.