Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury

Frontiers in Neuroscience, 2018 · DOI: 10.3389/fnins.2018.00341 · Published: May 23, 2018

Simple Explanation

Peripheral nerve injuries often result in incomplete motor function recovery. This study explores whether resveratrol, known for its nervous system benefits, can speed up nerve regeneration and motor repair after such injuries. The study found that resveratrol treatment alleviated motor deficits caused by sciatic nerve crush injury in rats within 10 days. The treatment also increased the number of axons, indicating enhanced nerve regeneration. Resveratrol activates a signaling pathway involving p300 acetyltransferase and VEGF, which contributes to faster nerve regeneration and motor repair. This suggests resveratrol's potential as a therapy for peripheral nerve injuries.

Study Duration

10 days

Participants

Adult Sprague Dawley rats (male, 200–220 g)

Evidence Level

Not specified

Key Findings

1
Daily resveratrol treatment alleviated motor deficits caused by sciatic nerve crush injury in rats within 10 days, suggesting rapid motor repair.
2
Resveratrol increased the number of axons in the distal part of the injured nerve, indicating enhanced nerve regeneration.
3
Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, contributing to accelerated nerve regeneration and motor repair.

Research Summary

This study investigates the potential of resveratrol to promote nerve regeneration and motor repair in a rat model of sciatic nerve crush injury. Resveratrol treatment was administered daily for 10 days, and histopathological and behavioral outcomes were examined. The results showed that resveratrol alleviated motor deficits, increased the number of axons in the injured nerve, and upregulated the expression of VEGF family proteins. These effects were associated with the activation of p300 acetyltransferase via Akt signaling. The study concludes that resveratrol promotes nerve regeneration and motor repair by activating p300 acetyltransferase-mediated VEGF signaling in the ventral spinal cord. This suggests a potential therapeutic role for resveratrol in treating peripheral nerve injuries.

Practical Implications

Therapeutic Potential

Resveratrol could be a potential therapeutic agent for promoting nerve regeneration and motor repair after peripheral nerve injuries.

Drug Development

The p300-VEGF signaling pathway could be a target for developing drugs to enhance nerve regeneration.

Rehabilitation Strategies

Resveratrol supplementation may enhance the effectiveness of rehabilitation programs for patients with peripheral nerve injuries.

Study Limitations

1
Motor deficits were not totally reversed by Res, potentially due to the short treatment period.
2
Further experiments should be performed on primary cultured neurons to obtain more reliable results.
3
Chromatin immunoprecipitation should be performed to examine the binding of p300 on the promoter or enhancer of VEGF genes.

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