Regenerative Medicine Research

KEY FINDING: 14-3-3 interacts with spastin at Ser233 in a phosphorylation-dependent manner, preventing spastin degradation via ubiquitination.

KEY FINDING: Overexpression of hBcl2 in BMSCs enhances their resistance to myelin debris-induced apoptosis in vitro.

KEY FINDING: Hyperbaric oxygen (HBO) intervention may protect against IVD degeneration via mir-107/Wnt3a-β-catenin signaling.

KEY FINDING: MSCs can differentiate into multiple cell lineages including osteoblasts, chondrocytes, adipocytes, fibroblasts, neurons and glial cells, making them appealing for therapeutic applications.

KEY FINDING: T-EVs enhanced the proliferation and antiapoptotic ability of NSCs in vitro and increased the shift from M1 to M2 polarization of reactive microglia, alleviating neuroinflammation.

KEY FINDING: LPS-induced zebrafish endotoxemia results in extravascular migration of neutrophils and macrophages and changes in the expression of tight junction proteins.

KEY FINDING: Graphene-based nanocarriers did not show cell toxicity and enhanced bone marrow derived mesenchymal stem cell (BM-MSC) proliferation by approximately 10% after 48 hours.

KEY FINDING: ASC secretome improves functional recovery of Xenopus laevis tadpoles after SCI, promoting significant functional recovery compared to neurobasal-treated animals.

KEY FINDING: Epigenetic reprogramming is a crucial step for generating iPSCs from somatic cells, as this process can determine their quality, safety and pluripotency. However, epigenetic reprogramming is often incomplete or inefficient, thus leading to residual epigenetic memory or aberrant epigenetic marks in iPSCs.

KEY FINDING: M2-MG promoted axon growth when co-cultured with DRGs in vitro.