14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention

The study investigates how the protein 14-3-3 interacts with another protein, spastin, to help nerve cells regrow after spinal cord injury. They found that 14-3-3 binds to spastin when it's phosphorylated, protecting it from being broken down. A drug called Fusicoccin (FC-A), which makes 14-3-3 work better, was used to see if it could improve nerve regeneration and movement after spinal cord injury in mice. The researchers discovered that FC-A did promote recovery, but only when spastin was active. The findings suggest that targeting the interaction between 14-3-3 and spastin could be a new way to treat spinal cord injuries, helping nerves to regenerate and improve movement.

• 1
  14-3-3 interacts with spastin at Ser233 in a phosphorylation-dependent manner, preventing spastin degradation via ubiquitination.
• 2
  The 14-3-3 agonist FC-A enhances nerve regeneration and locomotor improvement in spinal cord injury models.
• 3
  FC-A-mediated benefits require spastin activation, as demonstrated by the reversal of these effects with spastazoline.