Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,311-1,320 of 2,298 results
Cell Transplantation, 2024 • January 31, 2024
This study investigates the role of GPNMB in improving neural injury after SCI by promoting autophagy through in vivo and in vitro experiments. The research indicates that GPNMB improves motor functio...
KEY FINDING: GPNMB promotes motor function recovery after SCI, as evidenced by improved BBB and LSS scores, and reduced error rates in the grid error experiment.
Regenerative Biomaterials, 2024 • January 27, 2024
The study investigates the influence of micropatterned chitosan films on the polarization of rat skin precursor-derived Schwann cells (SKP-SCs), focusing on morphology, genic phenotype, and paracrine ...
KEY FINDING: SKP-SCs cultured on 30lm size microgroove surface showed better oriented alignment phenotype.
Journal of Nanobiotechnology, 2024 • December 6, 2024
This is a correction article for a paper published in the Journal of Nanobiotechnology. The correction addresses an error found in Figure 2D of the original publication. The corrected figure is includ...
KEY FINDING: An error was identified in the original article's Fig. 2D regarding the colony formation of Schwann cells in the EXO-1 μg/mL group.
Stem Cell Research & Therapy, 2024 • February 21, 2024
The study compared the efficacy of different FGF2 isoforms (18, 23, and 31 kD) overexpressed in hESCs for treating spinal ventral root avulsion in rats, using HFB for root repair. The 31 kD isoform sh...
KEY FINDING: hESCs overexpressing the 31 kD isoform of FGF2 showed superior neuroprotective effects compared to other isoforms and wild-type hESCs after ventral root avulsion.
Stem Cell Research & Therapy, 2024 • February 7, 2024
This study explored the heterogeneity of human UC-MSCs and identified the LRP1high subpopulation as capable of improving ovarian function in aged and POF mice. The LRP1high subpopulation improves ov...
KEY FINDING: Human UC-MSCs can be divided into three subtypes: mesenchymal stem cells, multilymphoid progenitor cells, and trophoblasts.
BMC Veterinary Research, 2024 • February 8, 2024
This study compared the therapeutic effects of stem cells and stem cell-derived exosomes in treating induced multiple sclerosis (MS) in dogs. Both treatments were administered intrathecally, and their...
KEY FINDING: Both stem cell and exosome treatments improved clinical signs in dogs with induced MS compared to the control group. Magnetic resonance imaging (MRI) showed a resolution of hyperintense lesions in the treated groups by the end of the study.
Open Life Sciences, 2024 • January 16, 2024
This study investigates the potential of human neural stem cells (hNSCs) as a cell-based therapy for Parkinson's disease (PD) using a rat model. The research demonstrates that hNSCs transplantation im...
KEY FINDING: Rats injected with 6-OHDA showed significant motor function deficits, which were restored by hNSCs treatment.
Inflammation and Regeneration, 2024 • January 1, 2024
This study investigates the time-course effects of hepatocyte growth factor (HGF) on spinal cord injury (SCI) using RNA-seq data to identify early, continuous, and delayed effects of HGF. The research...
KEY FINDING: The study identified three distinct components in the effects of HGF: early effects, continuous effects, and delayed effects, each operating at different times post-SCI.
Journal of Orthopaedic Surgery and Research, 2024 • January 1, 2024
This study investigates the therapeutic potential of exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs) in treating spinal cord injury (SCI). The findings suggest that UC-MSC-derive...
KEY FINDING: UC-MSC-derived exosomes improved motor ability in SCI rats compared to those without exosome treatment.
Stem Cell Research & Therapy, 2024 • April 2, 2024
This study investigates the efficacy of transplanted cells using stepwise combined cell therapy with human mesenchymal stem cells (hMSC) and induced pluripotent stem cell (iPSC)-derived motor neuron p...
KEY FINDING: Stepwise combined cell therapy can induce alterations in the microenvironment for effective cell therapy in SCI.