Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,291-1,300 of 2,298 results
Biomaterials, 2024 • March 1, 2024
This study presents the design of a delivery vehicle customized for transplantation of human cortical projection neurons into the injured cervical spinal cord, utilizing a family of SHIELD gels with d...
KEY FINDING: SHIELD with the RGDS ligand demonstrated the highest cell viability and the most robust neurite outgrowth in vitro.
Genes, 2023 • December 8, 2023
This study compares the transcriptomic responses of axolotls and rodents after spinal cord injury (SCI) to identify gene expression differences during the initial days post-injury, aiming to find tran...
KEY FINDING: Immune-related processes increase shortly after SCI in both axolotls and rodents; however, rodents show a more pronounced immune response.
Advanced Science, 2024 • December 25, 2023
The study developed LMGDNPs, injectable hydrogel microspheres, to address the nutrient imbalance and harsh microenvironment in degenerated intervertebral discs (IVD). LMGDNPs promoted cell survival an...
KEY FINDING: LMGDNPs showed a delayed release of lactate oxidase (LOX) and effectively consumed lactate, a harmful metabolic byproduct, creating a more favorable environment for cells.
Regenerative Therapy, 2024 • November 22, 2023
This study explores the potential of dorsal root ganglion (DRG) neurons to enhance the axon outgrowth of spinal motor neurons (SMNs) in an inhibitory environment mimicking spinal cord injury (SCI). Us...
KEY FINDING: Co-culturing DRGs and SMNAs increased SMNA axonal length by 32.1%.
Frontiers in Neuroscience, 2023 • December 14, 2023
Spinal cord injury (SCI) leads to motor, sensory, and autonomic dysfunctions due to inflammation, impaired axonal regeneration, and neuronal death. Regenerative treatments, especially cell and extrace...
KEY FINDING: Hydrogel-encapsulated EVs enhance exosome efficacy by maintaining bioactivity, protecting EVs from rapid clearance, and facilitating sustained release at the target site.
Frontiers in Pharmacology, 2023 • December 11, 2023
This study analyzes research on cell transplantation for TSCI from 2013 to 2023, identifying key countries, institutions, and researchers in the field. The number of publications in the field showed a...
KEY FINDING: Mainland China and the United States are the leading countries in cell transplantation research for TSCI.
Theranostics, 2024 • January 1, 2024
This study identifies a unique subpopulation of bone marrow mesenchymal stem cells (BMSCs), CD271+CD56+ BMSCs, with the ability to promote axon regeneration after spinal cord injury (SCI). The exosome...
KEY FINDING: CD271+CD56+ BMSC-Exos hydrogel implantation increased expression of NF and synaptophysin, markers of axon regeneration and synapse formation, respectively, in an SCI model.
International Journal of Surgery Case Reports, 2024 • January 2, 2024
This case report describes the successful treatment of a 64-year-old male with a spinal cord injury using percutaneous laser disc decompression (PLDD) combined with umbilical cord-derived mesenchymal ...
KEY FINDING: PLDD significantly reduced the patient's discomfort within 24 hours.
Neurospine, 2023 • September 25, 2023
The study aimed to determine whether mesenchymal stem cells (MSCs) transplantation combined with electroacupuncture (EA) treatment could decrease the proportion of proinflammatory microglia/macrophage...
KEY FINDING: MSCs+EA treatment reduced the proportion of pro-inflammatory M1 subtype microglia/macrophages and increased the differentiation of anti-inflammatory M2 phenotype cells.
Computational and Structural Biotechnology Journal, 2024 • December 19, 2023
This study investigates the spontaneous regeneration of CCKergic descending axons in larval lampreys following a complete SCI. The research demonstrates the partial regeneration of CCKergic axons, wit...
KEY FINDING: CCKergic axons partially regenerate after complete SCI in lampreys, reaching approximately 81% of the axonal profiles seen in uninjured controls by 10 weeks post-injury.