Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 251-260 of 639 results
Advanced Science, 2024 • March 21, 2024
The study introduces a novel nano complex designed for targeted repair of spinal cord injuries (SCI). The nano complex, consisting of a microRNA-loaded core camouflaged by a stem cell membrane modifie...
KEY FINDING: The nano complex promotes axon regrowth, modulates the local inflammatory microenvironment, and enhances functional recovery of SCI in mice, without causing treatment-related secondary injury.
Drug Design, Development and Therapy, 2024 • April 29, 2024
This paper provides a comprehensive review of the potential molecular biology mechanisms of hydrogen therapy and its application in treating SCI. Hydrogen has been proven to possess anti-inflammatory,...
KEY FINDING: Hydrogen exhibits selective antioxidant action by eliminating excessive harmful free radicals and alleviating cellular damage, thereby promoting recovery from conditions such as cerebral ischemia.
Frontiers in Neurology, 2024 • May 9, 2024
This case report describes a 31-year-old man who developed isolated unilateral brachial plexus injury following acute carbon monoxide (CO) poisoning. The patient presented with weakness and sensory de...
KEY FINDING: A 31-year-old man developed left brachial plexopathy after CO poisoning, confirmed by electrophysiological studies showing severe abnormalities in the upper and moderate abnormalities in the middle branches.
Frontiers in Pharmacology, 2024 • May 15, 2024
This editorial highlights the potential of natural products, medicinal foods, and herbal medicines in treating bone metabolism diseases and bone-related tumors. The included research articles explore ...
KEY FINDING: Tea-Seed Oil (TSO) contains components with antibacterial properties, potentially acting through pathways like PI3K-AKT and MAPK.
Arch Bone Jt Surg, 2024 • June 1, 2024
Spinal cord injury (SCI) is a complex and incurable condition causing significant damage. While advancements in managing SCI have improved, a complete treatment for humans remains elusive due to the i...
KEY FINDING: The pathophysiology of SCI consists of a two-phase process: the primary mechanical injury and the subsequent cascade of auto-destructive damages. This cascade leads to inflammation, hemorrhage, demyelination, axon disruption, apoptosis, and necrosis.
Genes & Diseases, 2024 • June 28, 2023
The study evaluated the efficacy and safety of NeuroWell, Deanxit, and their combination in treating mild-to-moderate depression through a randomized clinical trial. Results indicated that both NeuroW...
KEY FINDING: Both Deanxit and NeuroWell reduced the Hamilton anxiety scale and Hamilton depression scale scores compared to the placebo.
PLoS ONE, 2024 • October 31, 2024
This study used concept mapping to explore and prioritize content for a medication self-management toolkit for adults with SCI/D, caregivers, and healthcare providers. The final concept map contained ...
KEY FINDING: The final concept map included eight clusters, each representing a key content area for the medication self-management toolkit.
European Journal of Case Reports in Internal Medicine, 2024 • October 10, 2024
This case study presents a respiratory rehabilitation treatment involving combined oxygen therapy (O2) administered by high flow cannula (HFC) and Venturi mask (VM) in a patient with cervical spinal c...
KEY FINDING: The combined protocol of nighttime oxygen with high flow cannula and daytime Venturi mask improves intensive motor training of patients.
CANCER BIOLOGY & THERAPY, 2024 • December 3, 2024
This study investigates the efficacy of dinaciclib, a Cdk inhibitor, in treating biliary tract cancer (BTC) using in vitro models. The findings indicate that dinaciclib reduces cell viability, ATP lev...
KEY FINDING: Dinaciclib reduces cell viability, ATP levels, and proliferation rates in BTC cells.
Frontiers in Pharmacology, 2024 • December 12, 2024
The study investigates the molecular mechanisms of tomatidine in modulating the inflammatory response and promoting functional rehabilitation after SCI. Results show that tomatidine can alleviate neur...
KEY FINDING: Tomatidine promotes neuronal damage recovery and reduces histopathological changes in spinal cord tissues and LPS-induced PC-12 cells.