The efﬁcacy and safety of NeuroWell antidepressant dietary supplement, Deanxit, and their combination in the treatment of mild-to-moderate depression: A randomized clinical trial

Genes & Diseases, 2024 · DOI: https://doi.org/10.1016/j.gendis.2023.101171 · Published: June 28, 2023

Simple Explanation

This study investigates the effectiveness and safety of NeuroWell, an antidepressant dietary supplement, compared to Deanxit, a common antidepressant, and their combination for treating mild-to-moderate depression. The research involved a 12-week randomized clinical trial with 200 participants and found that both NeuroWell and Deanxit improved anxiety and depression symptoms. The combination of NeuroWell and Deanxit showed the most significant improvement, and NeuroWell was found to be more effective than Deanxit in improving sleep disorders over the long term.

Study Duration

12 weeks

Participants

200 participants with mild-to-moderate depression

Evidence Level

Randomized clinical trial

Key Findings

1
Both Deanxit and NeuroWell reduced the Hamilton anxiety scale and Hamilton depression scale scores compared to the placebo.
2
The combination of Deanxit and NeuroWell showed the largest decreases in both the Hamilton anxiety scale and Hamilton depression scale scores.
3
NeuroWell was found to be more effective in improving sleep disorders compared with Deanxit in the longer term.

Research Summary

The study evaluated the efficacy and safety of NeuroWell, Deanxit, and their combination in treating mild-to-moderate depression through a randomized clinical trial. Results indicated that both NeuroWell and Deanxit improved anxiety and depression, with the combination showing the most significant effects. NeuroWell demonstrated superior long-term efficacy in improving sleep disorders compared to Deanxit, suggesting it as a potential treatment option for depression-related sleep disturbances.

Practical Implications

Alternative Treatment

NeuroWell presents a potential alternative or complementary treatment option for individuals with mild-to-moderate depression, particularly those seeking natural remedies.

Improved Sleep Quality

The finding that NeuroWell is more effective in improving sleep disorders compared to Deanxit suggests its utility in managing depression-related sleep disturbances.

Combination Therapy

The combination of NeuroWell and Deanxit may offer enhanced therapeutic benefits for some patients, warranting further investigation into optimal treatment strategies.

Study Limitations

1
The study duration was limited to 12 weeks, which may not be sufficient to fully assess the long-term effects of NeuroWell.
2
The sample size of 200 participants may limit the generalizability of the findings to broader populations.
3
The study focused on mild-to-moderate depression, and the results may not be applicable to individuals with severe depression.

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