Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 241-250 of 639 results
Frontiers in Pharmacology, 2023 • September 20, 2023
The study uses a systems pharmacology approach to identify a four-drug combination (IL-6, HU-210, Taxol, and APC) that promotes axonal regeneration after injury in the rat optic nerve crush model. The...
KEY FINDING: The combination of IL-6 and HU-210 stimulates neurite outgrowth in an inhibitory environment by promoting neuroprotection and enabling neurite outgrowth.
Frontiers in Neuroscience, 2023 • October 10, 2023
This review assesses the potential of astaxanthin (AST) for treating spinal cord injury (SCI) in rats, focusing on neurological roles and clinical translation potential. Meta-analyses revealed that AS...
KEY FINDING: AST treatment in rats with SCI shows increased Basso, Beattie, and Bresnahan (BBB) scores, indicating improved locomotor function recovery compared to controls.
Top Spinal Cord Inj Rehabil, 2023 • July 1, 2023
This study investigated the effects of salsalate on fasting and postprandial glycemic, lipidemic, and inflammatory responses in persons with tetraplegia. The main findings were that salsalate signific...
KEY FINDING: Salsalate significantly reduced fasting and postprandial glucose values in persons with tetraplegia.
JBMR Plus, 2023 • December 1, 2023
The study demonstrates the efficacy of Siglec-15 Ab (NP159) in reducing bone resorption after acute SCI while maintaining bone formation capacity in rats. NP159 almost fully prevents the SCI-induced l...
KEY FINDING: NP159 treatment almost completely prevents the deterioration of bone after SCI, including loss of bone mineral density, trabecular bone volume, trabecular connectivity, and bone stiffness.
Journal of Nanobiotechnology, 2024 • December 6, 2023
This study developed electroconductive hydrogels composed of tannic acid (TA) and polypyrrole (PPy), incorporating exosomes with immunomodulatory properties to enhance spinal cord injury (SCI) repair....
KEY FINDING: M2-Exos-laden electroconductive hydrogels stimulate the growth of neural stem cells and axons in the dorsal root ganglion and modulate microglial M2 polarization.
bioRxiv preprint, 2023 • December 14, 2023
The study demonstrates that a triple combination formulation (TCF) containing the HDAC inhibitor vorinostat can effectively treat chronic neuropathic pain in a spared nerve injury (SNI) rat model. A s...
KEY FINDING: A single injection of the TCF significantly reduced mechanical allodynia (pain from normally non-painful stimuli) for up to four weeks in SNI rats.
BMC Pharmacology and Toxicology, 2024 • January 1, 2024
This study examined the efficiency of fixed-dose enoxaparin for VTE prophylaxis in rehabilitation patients after SAIS or SCI. The study found that a fixed dose may be inadequate for a significant prop...
KEY FINDING: Fixed-dose enoxaparin prophylaxis resulted in sub-prophylactic anti-Xa levels in 19% of patients and supra-prophylactic levels in 7.9% of patients.
Pharmaceuticals, 2024 • January 4, 2024
This study was an open label, single arm, prospective pilot study to evaluate the feasibility of treating people with TSCI with oral selenium and vitamin E. Four subjects completed the full twelve-mon...
KEY FINDING: Combination treatment with vitamin E and selenium was demonstrated as safe for TSCI patients, with no adverse events related to study medications.
Cells, 2024 • February 27, 2024
This review summarizes the combinatorial effects of rehabilitation and various medical agents in spinal cord injury (SCI) treatment, based on 43 articles. The medical agents are categorized into neuro...
KEY FINDING: Rehabilitation promotes various recovery processes, including regeneration of tracts, neuroprotection, scar tissue reorganization, plasticity of spinal circuits, and enforcement of the musculoskeletal system, which can be enhanced by medication.
Cureus, 2024 • February 12, 2024
This case report highlights the efficacy of a tailored physiotherapy rehabilitation approach in restoring function in a patient with quadriparesis following cervical spine trauma. The successful outco...
KEY FINDING: The patient demonstrated significant improvements in muscle strength, joint range of motion, and overall functional abilities through the rehabilitation program.