Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 161-170 of 639 results
Medicine, 2023 • January 1, 2023
The article reviews the development and impact of onabotulinumtoxinA (Botox) for the treatment of neurogenic detrusor overactivity (NDO) and overactive bladder (OAB). It highlights the unmet needs in ...
KEY FINDING: OnabotulinumtoxinA (Botox) significantly reduces urinary incontinence episodes in patients with NDO and OAB compared to placebo.
Biomedicines, 2023 • July 18, 2023
This study investigated the effect of local delivery of methylprednisolone succinate (MPS) combined with a tri-block copolymer (TBC) in rats with spinal cord injury (SCI). The results showed that loca...
KEY FINDING: Local application of methylprednisolone succinate in combination with block copolymer leads to recovery of center excitability by 21 days after injury.
Pharmaceuticals, 2023 • July 19, 2023
This study evaluates the analgesic effects of mirogabalin in a mouse model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve. The results indicate that mirogabalin ...
KEY FINDING: A single dose of mirogabalin is more effective than pregabalin in reducing tactile hypersensitivity in mice with nerve injury.
Journal of Translational Medicine, 2023 • August 2, 2023
Sciatic nerve crush led to motor dysfunction, reduction in exploration behavior, and a robust increase in mechanical and thermal hypersensitivity that were found to be mediated by neuroinflammation, n...
KEY FINDING: HBOT alleviates mechanical and thermal hypersensitivity and motor dysfunction following sciatic nerve crush (SNC).
Journal of Orthopaedic Surgery and Research, 2023 • September 28, 2023
The study aimed to elucidate the mechanism of action of DHJSD on NP by identifying and analyzing active components, target genes and related signaling pathways, and validating the results in a CCI rat...
KEY FINDING: DHJSD treatment repaired the CCI-induced inflammatory reaction in the spinal cord while regulating the expression of ACHE, NOS2, MAPK3, PTGS2, AKT1, and PPARG mRNA.
Drug Design, Development and Therapy, 2023 • August 23, 2023
EH inhibited thrombosis after SCI in a dose-dependent manner. Application of EH did not increase bleeding in the injured SC or damage nerve function. EH may provide a safe and effective anticoagulant ...
KEY FINDING: EH inhibited thrombosis in a dose-dependent manner by reducing the wet weight and dry weight of the thrombus.
bioRxiv preprint, 2023 • August 14, 2023
This study investigates the contribution of RVM serotonergic neurons to pain processing in the spinal trigeminal nucleus caudalis (SpVc) in acute and chronic pain models in mice. The findings suggest ...
KEY FINDING: Optogenetic activation of RVM serotonergic afferents in the spinal cord produces mechanical hypersensitivity and conditioned place aversion in naïve mice.
Heliyon, 2023 • August 21, 2023
This study investigated the efficacy of combining N-acetylcysteine (NAC) and primrose in treating traumatic spinal cord injury (SCI) in rats. The results indicated that the combined administration of ...
KEY FINDING: The combination of NAC and primrose significantly improved antioxidant biochemical markers in rats with traumatic SCI by day 14.
Journal of Traditional Chinese Medicine, 2023 • August 2, 2023
The study evaluated the effects of berberine on morphine analgesia, tolerance, and hyperalgesia in mice, utilizing acute, chronic, and established morphine tolerance models. The researchers measured p...
KEY FINDING: Berberine can prolong the duration of morphine analgesia.
Bioeng Transl Med, 2023 • May 25, 2023
This research introduces a thermosensitive hydrogel-based GPR124 delivery strategy for early intervention in SCI, demonstrating notable physicochemical effects that inhibit BSCB disruption and promote...
KEY FINDING: GPR124 expression decreases post-SCI, and recombinant GPR124 can partially alleviate BSCB disruption by restoring tight junctions and promoting endothelial cell migration and tube formation.