Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 171-180 of 639 results
Neural Regeneration Research, 2024 • March 1, 2024
This review focuses on the role of CD36, a scavenger receptor, in central nervous system (CNS) diseases and explores potential therapeutic strategies involving CD36 antagonists. The review discusses t...
KEY FINDING: CD36 mediates endothelial dysfunction, oxidative stress, mitochondrial dysfunction, and inflammatory responses, contributing to CNS diseases.
Korean J Pain, 2023 • August 1, 2023
This systematic review and meta-analysis evaluated the efficacy of muscimol in ameliorating nerve injury-related neuropathic pain based on preclinical studies. The study found that muscimol is effecti...
KEY FINDING: Muscimol significantly reduces mechanical allodynia (SMD = 1.78 [1.45–2.11]; P < 0.0001; I2 = 72.70%), mechanical hyperalgesia (SMD = 1.62 [1.28–1.96]; P < 0.0001; I2 = 40.66%), and thermal hyperalgesia (SMD = 2.59 [1.79–3.39]; P < 0.0001; I2 = 80.33%).
Medicina, 2023 • September 17, 2023
This study investigates the effects of hyperbaric oxygen therapy (HBO) and antioxidant supplementation with Filipendula ulmaria extract, individually and simultaneously, in treating thermal skin injur...
KEY FINDING: Simultaneous administration of hyperbaric oxygen therapy and antioxidant supplementation with Filipendula ulmaria extract significantly ameliorated the macroscopic and histopathological characteristics of the wound area and healing.
Pharmaceuticals, 2023 • September 7, 2023
The study explores the effects of ∆8-THC on neuronal cell death and recovery in a trauma-injured NSC-34 motoneuron cell line model. Traumatic scratch injury was induced, and cells were pretreated with...
KEY FINDING: ∆8-THC triggers cytoskeletal remodeling, potentially through activation of the Janus Kinase Signal Transducer and Activator of Transcription (JAK/STAT) signaling pathway and the Mitogen-Activated Protein (MAP) Kinase signaling pathway.
Pharmaceutics, 2023 • August 29, 2023
Salvianolic acid B, extracted from Danshen, exhibits diverse pharmacological effects, including antitumor, anti-inflammatory, antioxidant, and neuroprotective activities, making it a valuable compound...
KEY FINDING: Salvianolic acid B demonstrates antitumor effects by inducing apoptosis, autophagy, and oxidative stress, enhancing T cell activity, and inhibiting EMT and tumor cell proliferation across various cancers.
Frontiers in Neuroscience, 2023 • September 12, 2023
This systematic review investigated the neuroprotective effects of crude extracts, compound, and isolated molecules obtained from plants in different CNS lesions. Fourteen out of 5,521 studies were se...
KEY FINDING: Crude extracts, compounds, and isolated molecules obtained from plants showed neuroprotective effects against CNS injuries.
Immun Inflamm Dis, 2023 • September 5, 2023
This study revealed that the bioactive compound AF extracted from a peony (R. Paeoniae Alba) could efficiently improve motor function and reduce the loss of neuron cells in SCI rats. AF could reduce i...
KEY FINDING: Albiflorin (AF) administration alleviated motor dysfunction caused by acute SCI in a dose-dependent manner, improving the balancing ability of rats after acute SCI induction.
Frontiers in Pharmacology, 2023 • September 14, 2023
This study analyzed adverse event (AE) reports of dalfampridine from the FDA Adverse Event Reporting System (FAERS) to investigate its post-marketing safety. The analysis identified 335 AE signals, wi...
KEY FINDING: The study identified 335 AE signals related to dalfampridine, with a higher occurrence in females and individuals aged 45–65, aligning with MS epidemiology.
Cureus, 2023 • September 2, 2023
Interventional procedures and drug therapy to reduce pain may introduce iatrogenic side effects. These adverse events range from those that are merely bothersome to those that reduce the quality of li...
KEY FINDING: Interventional pain procedures can lead to nerve or vascular injuries, spinal cord trauma, and epidural abscesses, though these are rare.
JCI Insight, 2023 • October 12, 2023
This study demonstrates that spinal Npy1r-expressing DH interneurons that coexpress Grp are evolutionarily conserved across rodent, nonhuman primate, and human and are necessary for the efficacy of sp...
KEY FINDING: Y1-INs in the spinal dorsal horn are excitatory neurons that segregate into three distinct subpopulations based on coexpression of Npy1r with Grp, Npff, or Cck.