Pharmacology Research

KEY FINDING: Emodin elevated response latency and delayed the onset of mechanical hyperalgesia in rats with CCI on days 7, 14, and 21.

KEY FINDING: H2S exhibits neuroprotective properties by reducing oxidative stress, lipid peroxidation, and neuroinflammation. It also inhibits processes associated with apoptosis, autophagy, ferroptosis, and pyroptosis.

KEY FINDING: Bexarotene reduces collagen deposition and the number of pathological neurons in the injured spinal cord.

KEY FINDING: Repeated opioid treatment reduces mGluR5 protein levels in the DRG but increases them in the spinal cord, suggesting trafficking from DRG to spinal cord.

KEY FINDING: KCL-286 was well tolerated by healthy human participants following doses that exceeded potentially clinically relevant plasma exposures based on preclinical in vivo models.

KEY FINDING: Autophagy flow is blocked in the spinal dorsal horn of mice with chronic constriction injury (CCI), indicating impaired cellular cleaning processes during neuropathic pain.

KEY FINDING: MRI revealed increased signal throughout the spinal cord from C-1 to the conus medullaris with mild expansion consistent with transverse myelitis.

KEY FINDING: Higher concentrations of intrathecal levobupivacaine resulted in shorter onset times and longer maintenance times for anesthesia in rats.

KEY FINDING: Repeated mild blast traumatic brain injury (rmbTBI) results in mitochondrial impairment diffusely throughout the brain.

KEY FINDING: Taurine can modulate endoplasmic reticulum stress, Ca2+ homeostasis, and neuronal activity at the molecular level, effectively protecting against neurological disorders.