Efficacy of combination of N-acetylcysteine and primrose in spinal cord injury; an experimental study

Spinal cord injuries are a significant emergency with high morbidity and mortality, requiring urgent treatment. This study explores a new approach using a combination of primrose and N-acetylcysteine (NAC) to manage these injuries. The study involved testing primrose and NAC, both separately and combined, on rats with spinal cord injuries. The researchers then assessed neurological and motor function, along with measuring oxidative stress markers. The results indicated that the combined treatment of NAC and primrose was more effective than either treatment alone in improving biochemical and neurological functions after spinal cord injury.

• 1
  The combination of NAC and primrose significantly improved antioxidant biochemical markers in rats with traumatic SCI by day 14.
• 2
  The combined treatment also led to improved motor function in the rats, as assessed by inclined plane angle values by the 14th day.
• 3
  Primrose alone was found to be more effective than NAC alone in terms of oxidative biochemical markers, but less effective than the combined treatment.