Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 121-130 of 639 results
Frontiers in Endocrinology, 2023 • January 31, 2023
This study concludes that melatonin therapy was associated with improved testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress in male roden...
KEY FINDING: Melatonin therapy was associated with improved testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress in male rodents with physical, ischemic, and thermal testicular injuries.
Pain Research and Management, 2023 • February 8, 2023
This study investigates the potential of sEH inhibition, using TPPU, as a therapeutic target for paclitaxel-induced peripheral neuropathy (PIPN) in rats. The research aims to determine if TPPU can all...
KEY FINDING: TPPU restored mechanical and thermal thresholds in rats treated with nab-paclitaxel, indicating pain relief.
Toxins, 2023 • January 17, 2023
The study found that urethral BoNT-A injections can be effective for treating non-SCI voiding dysfunction, especially in patients with dysfunctional voiding (DV). Patients with detrusor underactivity ...
KEY FINDING: DV patients had a higher success rate (76.6%) than DU (50%) and PRES (45.8%) patients (p = 0.002) after urethral BoNT-A injection.
Exp Neurol, 2023 • May 1, 2023
This study investigates the direct effects of MAO inhibitors on brain mitochondrial bioenergetics and ROS production. The research focuses on clorgyline (MAO-A inhibitor), deprenyl/rasagiline (MAO-B i...
KEY FINDING: Selective inhibition of MAO-A by clorgyline increased mitochondrial oxygen consumption rate in State V(CI) respiration compared to vehicle treatment.
J Physiol, 2023 • April 1, 2023
This study provides the first evidence that bumetanide increases postsynaptic inhibition of the H-reflex after chronic SCI. By using in vivo intracellular recordings of motoneurons, we show that bumet...
KEY FINDING: A prolonged bumetanide treatment increases postsynaptic inhibition towards values observed in step-trained animals.
PLoS ONE, 2023 • March 13, 2023
This study evaluated the analgesic potential of CBD and BCP individually and in combination in a rat spinal cord injury (SCI) clip compression chronic pain model. Individually, both phytocannabinoids ...
KEY FINDING: Both CBD and BCP individually reduced tactile and cold hypersensitivity in male and female rats with SCI in a dose-dependent manner.
Annals of Medicine & Surgery, 2023 • March 24, 2023
This study evaluated the effect of olive leaf extract (OLE) on chronic spinal cord injury (SCI) in a rabbit model, focusing on inflammatory markers and neurotrophic factors. The results indicated that...
KEY FINDING: Chronic spinal cord compression increases serum levels of IL-6 and TNF-α and decreases serum levels of BDNF.
Research, 2023 • March 9, 2023
This study investigated the use of nucleoside-modified mRNA encoding human interleukin-10 (hIL-10) delivered via lipid nanoparticles (LNPs) to treat spinal cord injury (SCI) in rats. The intraspinal a...
KEY FINDING: Intraspinal delivery of hIL-10 mRNA-LNP significantly decreased the densities of CD68-, Iba-1-, and GSA-B4-positive cells compared with the injured spinal cords of SCI and mRNA-GFP animals at all examined time points.
J Vis Exp, 2024 • April 2, 2024
This protocol describes a method for disrupting the blood-spinal cord barrier (BSCB) in rats using low-intensity focused ultrasound (LIFU) and microbubbles (MBs). The technique involves animal prepara...
KEY FINDING: The concurrent application of LIFU sonication and MB administration is an effective technique for localized BSCB disruption, indicated by the presence of EBD extravasation into the spinal parenchyma.
Pharmaceutics, 2023 • March 6, 2023
The study investigates the pharmacokinetics of orally administered THC and CBD, as well as medical marijuana extracts, in mice, focusing on the concentrations in plasma, brain, and spinal cord. The TH...
KEY FINDING: Δ9-THC levels were higher in mice receiving the THC-rich extract compared to pure THC, suggesting improved bioavailability from the extract.