Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 131-140 of 639 results
Asian Spine Journal, 2023 • April 1, 2023
This systematic review and meta-analysis showed that epothilones had positive effects on the improvement of motor function in rats, and intraperitoneal injection of epothilones until a maximum of 1 da...
KEY FINDING: Epothilones have positive effects on motor improvement in animals with SCI.
CNS Neurosci Ther, 2024 • July 17, 2024
The study aimed to examine the involvement of L- and T-type VGCCs in the improvement of DSD following administration of 2,5-dimethoxy-4-iodophenyl-2-aminopropane hydrochloride in SCI rats. Intrathecal...
KEY FINDING: Intrathecal administration of 2,5-dimethoxy-4-iodophenyl-2-aminopropane hydrochloride or nifedipine increased voiding volume and enhanced voiding efficiency in rats with SCI.
Mater Sociomed, 2023 • March 1, 2023
This study evaluated the efficacy and safety of pregabalin in treating peripheral and central chronic neuropathic pain in 125 patients across five groups based on their underlying conditions. The resu...
KEY FINDING: Pregabalin significantly reduced pain intensity in patients with diabetes mellitus, after stroke, with lower back pain, and with multiple sclerosis.
Pharmaceuticals, 2023 • April 1, 2023
This study explored the therapeutic efficacy of hydrogen-rich saline (HRS) for spinal cord injury in rats, focusing on its neuroprotective, histological, and anti-inflammatory effects. The study found...
KEY FINDING: Hydrogen-rich saline treatment significantly decreased inflammation, as evidenced by decreased IL-6 and TNF-α levels in rats with spinal cord injuries.
Heliyon, 2023 • April 17, 2023
This randomized clinical trial evaluated the safety and effectiveness of intrathecal methyl-prednisolone (MP) compared to intravenous MP in patients with acute spinal cord injuries (SCI). The study fo...
KEY FINDING: The study found no significant difference in neurological outcomes or complication rates between the patients who received MP intrathecally and those who received it intravenously.
Cells, 2023 • April 27, 2023
The study investigates the therapeutic effects of simultaneously inhibiting AEA hydrolysis and oxygenation in treating neuropathic pain using a chronic constriction injury (CCI) mouse model. The combi...
KEY FINDING: The FAAH inhibitor PF04457845 and the substrate-selective COX-2 inhibitor LM4131 dose-dependently reduced thermal hyperalgesia and mechanical allodynia in the CCI mice.
Pharmaceutical Biology, 2023 • January 1, 2023
The study investigates the analgesic effects of daphnetin on neuropathic pain (NP) in rats with chronic constriction injury (CCI). Daphnetin treatment improved pain thresholds, reduced inflammatory ma...
KEY FINDING: Daphnetin improved thermal and mechanical withdrawal thresholds in rats with neuropathic pain, indicating reduced pain sensitivity.
Heliyon, 2023 • April 26, 2023
Asiatic acid (AA) demonstrates neuroprotective effects in various neurological conditions, including traumatic brain injury, spinal cord injury, cerebral ischemia, epilepsy, Parkinson’s disease, Alzhe...
KEY FINDING: AA can attenuate neurological deficits and reduce brain edema in traumatic brain injury (TBI) models by targeting the Nrf2/HO-1 pathway.
Stem Cells International, 2023 • May 4, 2023
This study investigates whether hydrogen can promote BMSC transplantation in treating SCI in rats, addressing the challenge of low cell survival rates in the inflammatory and oxidative stress-ridden S...
KEY FINDING: Hydrogen significantly enhances BMSC proliferation, migration, and tolerance to serum deprivation in vitro.
Stem Cells Translational Medicine, 2023 • May 20, 2023
This study demonstrates that acute metformin treatment can improve functional recovery after spinal cord injury (SCI) in both male and female mice. The drug's effectiveness is linked to its ability to...
KEY FINDING: Acute metformin treatment improves functional outcomes following SCI in both sexes.