Bumetanide increases postsynaptic inhibition after chronic SCI and decreases presynaptic inhibition with step-training

This study investigates bumetanide's effect on spinal inhibition after spinal cord injury (SCI), comparing it to step-training, which improves spinal inhibition by restoring chloride homeostasis. The research showed that bumetanide increased postsynaptic inhibition in SCI rats, hyperpolarizing the reversal potential for inhibitory postsynaptic potentials (IPSPs). However, in step-trained SCI rats, bumetanide decreased presynaptic inhibition, suggesting it might improve postsynaptic inhibition after SCI but hinder the recovery of presynaptic inhibition with step-training.

• 1
  A prolonged bumetanide treatment increases postsynaptic inhibition towards values observed in step-trained animals.
• 2
  Bumetanide increased postsynaptic inhibition by hyperpolarizing the reversal potential for IPSPs after SCI.
• 3
  An acute delivery of bumetanide decreases presynaptic inhibition evoked by PBSt group I afferents in SCI step-trained animals.