Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research

This study investigates the potential of olive leaf extract (OLE) to protect against chronic spinal cord injury (SCI) by reducing inflammation and promoting neurotrophic factor synthesis. The research focuses on how OLE affects pro-inflammatory cytokines (IL-6, TNF-α) and brain-derived neurotrophic factor (BDNF) levels, as well as functional motor outcomes in a rabbit model of chronic SCI. The study suggests that OLE may have neuroprotective qualities, potentially mitigating the harmful effects of chronic SCI by modulating inflammation and supporting neuronal health.

• 1
  Chronic spinal cord compression increases serum levels of IL-6 and TNF-α and decreases serum levels of BDNF.
• 2
  OLE 350 mg/kg body weight decreased serum levels of IL-6, TNF-α and increased functional motoric outcome, especially in prophylactic and concomitant therapy.
• 3
  Oleuropein has a potential effect to reduce the IL-6 and TNF-α in rabbit model of SCI, and the BDNF value risen after the administration of Oleuropein.