Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 51-60 of 200 results
Front. Surg., 2023 • May 26, 2023
This study evaluated the efficacy of 3D simulation/printing-assisted surgery for metastatic epidural spinal cord compression of the posterior column. The simulated group showed improvements in operati...
KEY FINDING: 3D simulation/printing-assisted surgery significantly reduced operation time compared to the non-simulated group.
Front. Neurol., 2023 • May 25, 2023
This case report presents a rare instance of a 3-year-old boy with a lumbosacral dumbbell-shaped epithelioid MPNST, highlighting its uncommon manifestation and genetic underpinnings. Genetic testing i...
KEY FINDING: The patient had a novel germline mutation in the SMARCB1 gene, inherited from his father, suggesting a “second-hit loss”.
JCI Insight, 2023 • July 24, 2023
This study identifies OATP1B-type transporters as mediators of vincristine uptake in DRG neurons and demonstrates that inhibiting these transporters can prevent VIPN. Genetic deficiency or pharmacolog...
KEY FINDING: OATP1B3 (human) and OATP1B2 (mouse) are identified as neuronal transporters that regulate the uptake of vincristine into DRG neurons.
Heliyon, 2023 • July 11, 2023
This case report describes a successful treatment of a rare spinal cord tumor, spindle cell hemangioendothelioma (SCH), with a lower dose of radiation therapy (40Gy). The patient, who had residual tum...
KEY FINDING: A radiation dose of 40Gy was effective in controlling the SCH tumor and preventing recurrence in this case.
Diagnostics, 2023 • July 10, 2023
This study focuses on using MRI to evaluate bone metastases treated with palliative radiotherapy, aiming to correlate lesion volume reduction with improved symptom control. MRI is preferred due to its...
KEY FINDING: The primary objective is to assess the concordance between morphological (MRI-based) and clinical (symptom-based) methods in evaluating local control of bone metastases after radiotherapy.
Journal of Orthopaedic Surgery and Research, 2023 • July 3, 2023
Spinal metastasis is a common problem for cancer patients, leading to spinal cord and nerve root compression that causes pain and dysfunction. Evaluation systems like SINS and NOMS are increasingly us...
KEY FINDING: Open surgery can effectively alleviate pain resulting from spinal cord and nerve root compression, improve neurological symptoms, and correct or prevent vertebral deformities.
International Journal of Biological Sciences, 2023 • September 11, 2023
This study investigates the therapeutic potential of tofacitinib (TOF), a JAK inhibitor, for spinal cord injury (SCI) by examining its effects on microglial polarization and the JAK/STAT signaling pat...
KEY FINDING: TOF effectively improves motor dysfunction caused by spinal cord injury in rats, indicating its potential to promote functional recovery.
Cureus, 2023 • August 31, 2023
This case report describes the diagnosis and treatment of glioblastoma multiforme (GBM) in a 20-year-old Division I softball player. The athlete initially presented with numbness in her left hand, lea...
KEY FINDING: The initial presentation of GBM in this athlete was atypical, mimicking nerve-related issues in the upper extremity. This highlights the importance of considering a broad differential diagnosis, including brain tumors, even in young, athletic individuals with seemingly musculoskeletal symptoms.
Neurosurg Focus Video, 2023 • October 1, 2023
The video demonstrates a precise midline myelotomy technique for resecting spinal cord ependymomas, emphasizing dissection of the dorsal column to navigate the anatomical posterior median septum. This...
KEY FINDING: The posterior median septum is not linear or vertical, and its orientation can be deformed by tumor growth, making direct dissection of the dorsal column a safer approach for midline myelotomy.
Medicine, 2023 • November 3, 2023
This case report describes a 73-year-old female patient who experienced transient unilateral limb dysfunction following surgery for a thoracic spinal meningioma. The patient presented with numbness an...
KEY FINDING: Transient unilateral limb dysfunction can occur after surgery for intraspinal meningiomas, even without apparent spinal cord injury during the procedure.