Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 191-200 of 200 results
Frontiers in Bioengineering and Biotechnology, 2019 • October 15, 2019
This study aimed to identify alternative splicing events (ASEs) associated with prognosis and metastasis in kidney renal clear cell carcinoma (KIRC) using bioinformatic analysis of TCGA data. In this ...
KEY FINDING: Identified 6,081 overall survival-related ASEs (OS-SEs) in KIRC. A total of prognostic 6,081 overall survival-related ASEs (OS-SEs) were identified by univariate Cox regression analysis
OncoTargets and Therapy, 2019 • December 1, 2019
This study investigates the role of miR-26a-5p in osteosarcoma cells and finds that it is highly expressed in osteosarcoma cell lines compared to noncancerous cells, suggesting its involvement in oste...
KEY FINDING: miR-26a-5p is highly expressed in osteosarcoma cell lines compared to noncancerous cells, especially in U2OS cells.
Redox Biology, 2020 • May 21, 2020
This study investigates how glioblastoma (GBM) cells cope with high levels of reactive oxygen species (ROS). The researchers found that C/EBPβ, a transcription factor, regulates the expression of NQO1...
KEY FINDING: C/EBPβ is highly expressed in GBM tumors and correlates with poor patient survival rates.
Signal Transduction and Targeted Therapy, 2020 • June 15, 2020
This letter identifies CBP-dependent DVL2 acetylation at K68 as a novel regulator in Wnt3a-induced DVL signalosome formation. DVL2-K68 acetylation is critical for activation of downstream β-catenin si...
KEY FINDING: CBP-dependent acetylation of DVL2 at K68 promotes DVL2 signalosome formation.
J Vet Res, 2020 • January 1, 2020
This study determined the presence of nitric oxide synthesis isoforms (nNOS, iNOS, and eNOS) in thoracic spinal cord segments and nodose ganglia of rats with gamma-irradiated livers. The nNOS, iNOS, a...
KEY FINDING: nNOS immunoreactivity was found in the superficial lamina (lamina I–II) of the spinal cord of the rats with ionising radiation insult to the liver, and to a lesser extent in lamina III–IV.
J Hematol Oncol, 2020 • October 13, 2020
This study identifies MNPC, a dual inhibitor of NQO1 and GSTP1, as a potential therapeutic agent for glioblastoma (GBM). MNPC selectively inhibits the proliferation of GBM cells bearing the EGFRvIII m...
KEY FINDING: MNPC is a small molecule inhibitor that binds to both NQO1 and GSTP1 with high affinity and selectivity, inhibiting their enzymatic activities.
Nano Res., 2021 • May 1, 2021
This review explores the bioengineering of nano metal-organic frameworks (nMOFs) for cancer immunotherapy, highlighting their potential to overcome limitations in current immunotherapy techniques. The...
KEY FINDING: nMOFs possess superior features over conventional nanocarriers, including high porosity, large surface area, greater tunability, accurate structure, and inherent superior functions without extra loading of functional agents.
OncoTargets and Therapy, 2020 • January 1, 2020
This study investigates the role of lncRNA LINC00691 in osteosarcoma. It demonstrates that LINC00691 expression is downregulated in osteosarcoma cells and tissues. The study reveals that LINC00691 fun...
KEY FINDING: LINC00691 expression is decreased in osteosarcoma cells compared to control cells.
Eur Spine J, 2003 • November 19, 2002
This case report describes a 48-year-old man with an intramedullary schwannoma extending from the conus medullaris to T11, causing bilateral lower extremity weakness. Gross total resection of the tumo...
KEY FINDING: Schwann cells can indeed invade the central nervous system, as demonstrated by the presence of an intramedullary schwannoma within the conus medullaris.
Radiation Oncology, 2007 • June 30, 2007
The review summarizes experimental strategies for preventing and treating radiation-induced CNS toxicity, including neurocognitive decline and radiation necrosis, highlighting the importance of tailor...
KEY FINDING: Early intervention with agents like amifostine and growth factors (IGF-1, FGF-2) shows preliminary evidence of modulating the radiation response in the CNS and increasing long-term radiation tolerance.