Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 181-190 of 200 results
Neural Regen Res, 2018 • March 1, 2018
This study evaluated the effects of 125I radioactive seed implantation on the spinal cord of rabbits using diffusion tensor imaging (DTI) and pathological analysis. The results indicated that higher r...
KEY FINDING: Increased radiation dose (D90) correlated with aggravated pathological damage of neurons and microvessels in the gray matter and white matter.
Biotechnology Reports, 2018 • January 1, 2018
This study explores the use of the Proseek Single-Plex Protein Assay Kit System for detecting sAxl and Gas6 in HGG patients' blood, aiming for more sensitive detection than standard ELISA methods. The...
KEY FINDING: The Proseek method demonstrates higher sensitivity in detecting lower concentrations of Gas6 compared to the DuoSet sandwich ELISA method.
Neural Regen Res, 2018 • June 1, 2018
This study investigates the analgesic effect of AG490 on oxaliplatin-induced acute neuropathic pain in rats. The findings demonstrate that AG490 attenuates oxaliplatin-induced acute neuropathic pain b...
KEY FINDING: AG490 treatment significantly increased paw withdrawal threshold and tail withdrawal latency in rats with oxaliplatin-induced neuropathic pain, indicating reduced sensitivity to mechanical and cold stimuli.
Scientific Reports, 2018 • August 7, 2018
The study successfully delivered IFN-α mRNA to human skin explants using biolistic application. Optimized IFN-α mRNA sequence variants resulted in significantly higher IFN-α protein expression compare...
KEY FINDING: Skin explants remained viable and intact for at least five days, making them suitable for testing.
Front. Cell. Neurosci., 2018 • October 11, 2018
This study developed a reproducible in vitro model to study MPNST from isolated adult Schwann cells (iSCs) that following transplantation, share striking phenotypic resemblance to primary human MPNST ...
KEY FINDING: Adult rodent Schwann cells can be induced to form MPNST-like tumors after transplantation.
ONCOLOGY LETTERS, 2019 • January 1, 2019
The study characterized the expression profile of ING5 protein in normal mouse and human tissues, and human cancer tissues. ING5 expression was primarily detected in the cytoplasm of normal mouse and ...
KEY FINDING: ING5 expression varies in different tissues, with cytoplasmic localization being more common in normal mouse and human tissues.
Frontiers in Oncology, 2019 • February 1, 2019
This systematic review analyzed 33 studies on molecular targeted therapy (MTT) for chordoma, a rare bone malignancy affecting the spine and skull base. The review identified imatinib and erlotinib as ...
KEY FINDING: Imatinib and erlotinib were the most frequently used molecular targeted inhibitors (MTIs) for chordoma.
Neurotherapeutics, 2019 • March 6, 2019
This study investigated the efficacy of a double-targeted GMCSF-NgR-PirB nucleic acid vaccine as an immunotherapy strategy for spinal cord injury (SCI) in rats. The vaccine was designed to stimulate t...
KEY FINDING: The GMCSF-NgR-PirB nucleic acid vaccine stimulated the production of antibodies against NgR and PirB in rats.
Med Sci Monit, 2019 • June 24, 2019
This study evaluated prognostic factors for overall survival (OS) and cause-specific survival (CSS) in patients with non-metastatic osteosarcoma using the SEER database. Multivariable analysis identif...
KEY FINDING: Age, tumor size, grade, and AJCC T staging were independent prognostic factors for OS and CSS.
Orthopaedic Surgery, 2019 • October 1, 2019
This study aimed to identify prognostic factors and develop nomograms for predicting the overall survival (OS) and cause-specific survival (CSS) of patients with non-metastatic chondrosarcoma using da...
KEY FINDING: Age, gender, tumor size and extension, surgery, histological grade, and subtype were identified as independent prognostic factors for both overall survival (OS) and cause-specific survival (CSS).