Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 171-180 of 200 results
Cell Communication and Signaling, 2024 • August 6, 2024
This study confirms a myeloproliferative role of NLRP3 by demonstrating that the expression of NLRP3 and the NLRP3 inflammasome-related genes ASC, IL1B, and IL18 is increased in AML patient cells comp...
KEY FINDING: Elevated NLRP3 expression is associated with diminished overall survival in AML patients, suggesting a critical role in AML pathogenesis.
Frontiers in Neurology, 2024 • September 13, 2024
The study identified CELF4 as a central gene associated with immune infiltration among DEGs through bioinformatics analysis of microarray datasets. Previous research indicates that CELF4 may play a cr...
KEY FINDING: A total of 5,151 differentially expressed genes (DEGs) were identified between SP-EP and normal samples. These DEGs are involved in cellular processes like cell cycle regulation and cell sensitivity mechanisms, according to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.
Bioeng Transl Med, 2024 • May 1, 2024
The study developed injectable hydrogels for local, controlled release of protein therapeutics into tissue. The hydrogel, featuring slowly hydrolyzing linkers, prolongs the therapeutic effect, minimiz...
KEY FINDING: Anti-CD47 monoclonal antibodies incorporated into subsurface-injected hydrogel solutions exhibited cytotoxic activity against infiltrative high-grade glioma xenografts in the rodent brain.
Neural Regeneration Research, 2015 • February 1, 2015
This study investigated the involvement of the Notch pathway in the development of diffuse spinal cord astrocytomas by injecting CD133+ and CD133− cell suspensions into mice. Results showed xenografts...
KEY FINDING: Xenografts were observed on the brains of mice receiving CD133+ cell suspensions, with Notch-immunopositive expression in these xenografts.
Journal of Neuroinflammation, 2015 • June 11, 2015
This study demonstrates that DRα1-mMOG-35-55, a novel construct, can effectively treat EAE in MHC-mismatched mice by reducing CNS inflammation. The treatment's efficacy is potentially mediated by an i...
KEY FINDING: DRα1-mMOG-35-55 effectively treats EAE in MHC-mismatched C57BL/6 mice by reducing CNS inflammation.
Leukemia, 2016 • January 29, 2016
This study by the European Research Initiative on CLL (ERIC) identified and validated a flow-cytometric approach to reliably quantitate CLL cells to the level of 0.0010% (10 −5). A parallel analysis o...
KEY FINDING: A six-marker flow cytometry panel (CD19, CD20, CD5, CD43, CD79b, and CD81) was identified as reliable and convenient for identifying typical CLL cells.
Journal of Orthopaedic Surgery and Research, 2016 • January 1, 2016
This study evaluated the effects of x-ray irradiation on spinal cord regeneration in rats after injury. Rats were subjected to spinal cord injury and then treated with either 10 Gy or 20 Gy of x-ray i...
KEY FINDING: NF counts were higher in both 10-Gy and 20-Gy irradiated groups compared to the sham group at both 6 and 14 weeks after SCI, suggesting that x-ray treatment might promote the regeneration of the spinal cord central nervous system.
Nat Med, 2016 • July 1, 2016
This study introduces a novel xenotransplantation model using humanized ossicles to improve the engraftment of human hematopoietic cells, including leukemic cells. The humanized ossicles support robus...
KEY FINDING: Humanized ossicles exhibit robust engraftment of normal human hematopoietic stem and progenitor cells.
Nat Med, 2017 • March 1, 2017
This study provides a comprehensive assessment of epigenetic heterogeneity in Ewing sarcoma, highlighting the importance of non-genetic aspects in tumor heterogeneity. The research performed genome-sc...
KEY FINDING: Ewing sarcoma tumors displayed consistent DNA hypomethylation at enhancers regulated by the EWS-FLI1 fusion protein, indicating epigenomic enhancer reprogramming.
ONCOLOGY LETTERS, 2017 • January 1, 2017
The study investigates the expression profile of ING3 protein in both normal and cancerous tissues of mice and humans, using immunohistochemistry to determine its location within cells. Results indica...
KEY FINDING: ING3 protein is widely distributed in normal mouse tissues, particularly in the cytoplasm of cardiomyocytes, kidney, and skeletal muscle cells.