Identifying the Prognosis Factors and Predicting the Survival Probability in Patients with Non-Metastatic Chondrosarcoma from the SEER Database

Orthopaedic Surgery, 2019 · DOI: 10.1111/os.12521 · Published: October 1, 2019

Simple Explanation

This study aimed to identify factors that affect the survival of patients with non-metastatic chondrosarcoma, a type of bone cancer. The researchers used data from the SEER database and the First Affiliated Hospital of Zhengzhou University to analyze various factors and create nomograms to predict patient survival. The study found that age, gender, tumor size and extension, surgery, histological grade, and subtype were significant prognostic factors. Additionally, tumors in the trunk, radiotherapy, and chemotherapy were associated with poorer prognoses. The nomograms developed in this study can help oncologists predict the 3-year and 5-year survival probability of patients with non-metastatic chondrosarcoma. This can assist in making more accurate survival evaluations and treatment decisions.

Study Duration

2005-2014 (SEER database), 2011-2016 (First Affiliated Hospital of Zhengzhou University)

Participants

1267 patients (training set), 72 patients (testing set) with non-metastatic chondrosarcomas

Evidence Level

Not specified

Key Findings

1
Age, gender, tumor size and extension, surgery, histological grade, and subtype were identified as independent prognostic factors for both overall survival (OS) and cause-specific survival (CSS).
2
Chondrosarcomas located in the trunk, as well as radiotherapy and chemotherapy treatments, were correlated with a poorer prognosis.
3
The nomograms developed in this study demonstrated better accuracy in predicting survival compared to the traditional AJCC staging systems.

Research Summary

This study aimed to identify prognostic factors and develop nomograms for predicting the overall survival (OS) and cause-specific survival (CSS) of patients with non-metastatic chondrosarcoma using data from the SEER database and the First Affiliated Hospital of Zhengzhou University. The analysis revealed that age, gender, tumor size and extension, surgery, histological grade, and subtype are independent prognostic factors. Furthermore, the study found that chondrosarcomas in the trunk, radiotherapy, and chemotherapy were associated with poor prognosis. The nomograms developed in this study can accurately predict the 3-year and 5-year survival probability of patients with non-metastatic chondrosarcoma, offering a valuable tool for oncologists in making accurate survival evaluations.

Practical Implications

Improved Survival Prediction

The developed nomograms provide a more accurate tool for predicting survival probabilities compared to traditional staging systems.

Personalized Treatment Planning

Identifying independent prognostic factors allows for tailored treatment strategies based on individual patient characteristics.

Risk Stratification

The findings highlight the importance of considering tumor location, specifically tumors in the trunk, and the potential risks associated with radiotherapy and chemotherapy.

Study Limitations

1
Inaccurate information within the SEER database for certain variables.
2
Lack of data on pathologic fracture, surgical margin status, and incomplete radiotherapy and chemotherapy information.
3
Retrospective study design.

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