Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 141-150 of 200 results
Cancers, 2022 • January 29, 2022
The urinary bladder is an immunogenic organ. The occurrence of BC permanently alters the immune landscape of the bladder. Immunizing therapies, either as bladder instillation or as intravenously or or...
KEY FINDING: Durvalumab plus Oportuzumab monatox, Pembrolizumab, and Nadofaragene firadenovec (NF) show complete response (CR) rates of 41.6%, 40.6%, and 59.6% after 3 months.
Biomolecules, 2022 • March 12, 2022
This study identifies three L1 antagonistic mimetics—anagrelide, 2-hydroxy-5-fluoropyrimidine, and mestranol—that inhibit the migration of cultured tumor cells in an L1-dependent manner. The mimetics ...
KEY FINDING: Anagrelide, 2-hydroxy-5-fluoropyrimidine, and mestranol competitively inhibit antibody 324 binding to L1, suggesting they interfere with L1's function.
Nanomaterials, 2022 • March 30, 2022
This review highlights the potential of lipid-based nanomaterials in addressing bone complications, particularly bone metastasis, by offering targeted drug delivery and improved therapeutic efficacy. ...
KEY FINDING: Lipid-based nanocarriers can be modified with bisphosphonates to enhance their affinity for bone, allowing for improved drug delivery to targeted areas within the bone structure.
Pharmaceutics, 2022 • March 29, 2022
With the deep understanding of the effector mechanisms of immune cells, the biomimetic and materials-potentiated cell engineering is refreshing its meaning. The combination of cell or cell-derived com...
KEY FINDING: Materials-potentiated cell engineering strategies are to endow immune cells with different supportive components (also known as backpack strategies), or functional materials to enhance their anti-tumor effects, prevent and rescue their dysfunction, maintain and restore their anti-tumor phenotype
Disease Markers, 2022 • May 11, 2022
The study investigates the role of DYNC1H1 in LIHC using bioinformatics and experimental analysis, finding that DYNC1H1 expression is associated with clinicopathological features and poor prognosis. G...
KEY FINDING: DYNC1H1 expression levels were associated with T classification, pathologic stage, histologic grade, and serum AFP levels in LIHC patients.
J Neurosurg Case Lessons, 2021 • December 20, 2021
This case report describes an extremely rare instance of intradural extramedullary (IDEM) metastasis of parotid acinic cell carcinoma (ACC) in a 79-year-old male with a 29-year history of the disease....
KEY FINDING: The patient presented with progressive cervical myelopathy 29 years after initial diagnosis of parotid ACC, indicating a rare late recurrence and metastasis.
Cancers, 2022 • July 23, 2022
The purpose of this study was to retrospectively analyze the diagnostic accuracy of magnetic resonance imaging (MRI) examinations of the scrotum in comparison with standard ultrasound (US) and histopa...
KEY FINDING: MRI shows good sensitivity and specificity for the estimation of testicular tumors in this collective.
iScience, 2022 • August 19, 2022
Tetraspanins (TSPANs) are a class of four-transmembrane segmented proteins. The precise functions of TSPANs and their roles in pan-cancer are unclear. In this work, we analyzed 24 TSPAN family genes i...
KEY FINDING: TSPAN3-6, TSPAN9-11, TSPAN13-15, TSPAN17, TSPAN31, TSPAN33 are mainly upregulated, and TSPAN2, TSPAN7 are mainly downregulated.
npj Genomic Medicine, 2022 • August 8, 2022
Based on TCGA and TCGASpliceSeq databases, gene expression and the AS data of UCEC samples were retrieved. These findings indicate that HSPB1, a splicing factor, regulates the expression of ANKHD1-BP3 ...
KEY FINDING: An alternate terminator of ANKHD1 transcripts named ANKHD1-BP3 was found to be significantly related to metastasis and OS in UCEC and significantly associated with HSPB1.
Computational and Mathematical Methods in Medicine, 2022 • October 1, 2022
This study explores the role of TRIM28 in LIHC, finding that its expression is upregulated in tumors and associated with poor prognosis. The research identifies correlations between TRIM28 expression ...
KEY FINDING: High TRIM28 expression level was associated with T classification, pathologic stage, histologic grade, and serum AFP levels.