Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 151-160 of 200 results
Journal of Nanobiotechnology, 2022 • December 28, 2022
The study developed CaO2@mPDA-SH nanoparticles that can regulate the tumor microenvironment by consuming lactic acid and alleviating hypoxia. The nanoparticles promote immune responses, inhibit angio...
KEY FINDING: CaO2@mPDA-SH nanoparticles can dually regulate tumor hypoxia and lactic acid metabolism.
Advanced Science, 2023 • November 16, 2022
This study identifies cancer cell lines that are sensitive or resistant to OXPHOS inhibition and reveals that the NNMT-DNMT1 axis plays a critical role in determining cancer cell reliance on mitochond...
KEY FINDING: OXPHOS inhibition-sensitive cancer cells exhibit increased OXPHOS activity and silenced NNMT expression.
Frontiers in Bioengineering and Biotechnology, 2022 • December 5, 2022
The study aimed to explore a new microRNA (miRNA) which can bind to combining engineered exosomes for treatment of older OS patients. MiR-449a is down-regulated in osteosarcoma and suppresses cell pro...
KEY FINDING: MiR-449a is down-regulated in osteosarcoma and suppresses cell proliferation by targeting CCNB1.
Frontiers in Neurology, 2022 • December 12, 2022
This study analyzed clinical and imaging features of patients with cancer-related cryptogenic stroke (CCS) involving multiple brain circulations, aiming to improve early diagnosis. The research identi...
KEY FINDING: Patients with cancer-related cryptogenic stroke (CCS) exhibited significantly higher levels of D-dimer, fibrin degradation product (FDP), international normalized ratio (INR), neutrophil to lymphocyte ratio (NLR), and platelets to lymphocyte ratio (PLR) compared to non-cancer cryptogenic stroke patients.
The EMBO Journal, 2023 • February 17, 2023
This study identifies IFITM1 as a key repressor of brain metastatic colonization in lung cancer. Loss of IFITM1 promotes brain colonization, while high IFITM1 expression activates microglia and enhanc...
KEY FINDING: Loss of IFITM1 promotes brain colonization of human lung cancer cells, identified through in vivo genome-wide CRISPR-Cas9 screening.
Hereditas, 2023 • April 3, 2023
The study investigates the mechanism by which γ-T3, a form of vitamin E, regulates gastric cancer cells, focusing on its impact on gene expression and signaling pathways. RNA-seq analysis of γ-T3-trea...
KEY FINDING: γ-T3 treatment alters the expression of mRNA and ncRNA in gastric cancer cells, indicating a broad impact on cellular functions.
Frontiers in Immunology, 2023 • March 29, 2023
This study investigates the role of QPCTL in glioma, finding its expression elevated in tumor tissues and associated with poor prognosis. Bioinformatic analyses reveal QPCTL's involvement in cytokine ...
KEY FINDING: QPCTL expression is higher in glioma tumor tissue compared to normal tissue, and higher expression correlates with high-grade malignancy and advanced tumor stage.
Journal of Nanobiotechnology, 2023 • January 1, 2023
This is a correction article for the original article which studies Acidic and hypoxic tumor microenvironment regulation by CaO(2)-loaded polydopamine nanoparticles. The correction addresses an error ...
KEY FINDING: The authors identified an error in affiliation in the original article.
Cell, 2023 • July 20, 2023
The study identifies Quaking proteins (QKIs) as mRNA internal m7G binding proteins. QKI7 shuttles internal m7G-modified mRNAs into stress granules (SGs) under stress conditions, regulating mRNA metabo...
KEY FINDING: QKIs preferentially recognize internal mRNA m7G modifications.
The EMBO Journal, 2023 • July 10, 2023
This study conducted single-cell RNA and TCR repertoire sequencing of primary CC tissues and adjacent normal tissues to decode the heterogeneity of the TME. The intra- and inter-tumoral heterogeneity ...
KEY FINDING: Cytotoxic large-clone T cells are critical effectors in the antitumor response.