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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Musculoskeletal Medicine Research

Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.

Showing 21-30 of 278 results

AgingMusculoskeletal Medicine

Treatment and Outcome of Osteoporotic Thoracolumbar Vertebral Fractures With Anterior or Posterior Tension Band Failure (OF 5): Short-Term Results From the Prospective EOFTT Multicenter Study

Global Spine Journal, 2023 • January 1, 2023

This study evaluated surgical strategies for osteoporotic thoracolumbar fractures (OF 5) with anterior or posterior tension band failure, assessing complications and clinical outcomes. The results sho...

KEY FINDING: Surgical stabilization is an effective treatment for OF 5 fractures, leading to significant short-term improvements in functional outcome and quality of life.

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SurgeryOrthopedicsMusculoskeletal Medicine

Surgical timing prevails as the main factor over morphologic characteristics in the reduction by ligamentotaxis of thoracolumbar burst fractures

BMC Surgery, 2023 • June 8, 2023

This study evaluated the effectiveness of indirect reduction by ligamentotaxis in thoracolumbar burst fractures based on radiologic characteristics and procedure timing. The study found that postopera...

KEY FINDING: Ligamentotaxis significantly improved canal occupation, endplates distance, and vertebra height postoperatively.

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Spinal Cord InjuryResearch Methodology & DesignMusculoskeletal Medicine

Efficacy and Safety of Conservative Treatment Compared With Surgical Treatment for Thoracolumbar Fracture With Score 4 Thoracolumbar Injury Classification and Severity (TLICS) A Systematic Review and Meta-analysis

Clin Spine Surg, 2024 • June 1, 2024

This meta-analysis compared surgical and conservative treatments for thoracolumbar fractures with a TLICS score of 4. The study found that surgical treatment may offer benefits in terms of faster retu...

KEY FINDING: Surgical treatment resulted in a shorter length of returning to work compared to nonsurgical treatment.

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Spinal Cord InjuryRehabilitationMusculoskeletal Medicine

Heterotopic ossification after spinal cord injury: prevention and treatment – a sistematic review

Acta Ortop Bras, 2023 • January 1, 2023

This systematic review investigates methods to prevent and treat neurogenic HO in people with spinal cord injuries, analyzing retrospective studies ranging from level 3 to 4 of evidence. Resection sur...

KEY FINDING: Non-steroidal anti-inflammatory drugs (NSAIDs) are the best method for preventing heterotopic ossification if administered in the acute period after spinal cord injury.

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SurgeryOrthopedicsMusculoskeletal Medicine

The patient‑related factors in revision procedures on tibia of patients with osteogenesis imperfecta treated with the Peter‑Williams nail

Journal of Orthopaedic Surgery and Research, 2023 • June 23, 2023

This study explored patient-related factors affecting the revision procedures of tibia in patients with osteogenesis imperfecta treated with the Peter-Williams nail and investigated the relationship b...

KEY FINDING: The age of initial surgery significantly correlates with revision procedures (OR = 0.83, 95% CI 0.76–0.92, P < 0.001).

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NeurologyBiomechanicsMusculoskeletal Medicine

Regulation of Bone by Mechanical Loading, Sex Hormones, and Nerves: Integration of Such Regulatory Complexity and Implications for Bone Loss during Space Flight and Post-Menopausal Osteoporosis

Biomolecules, 2023 • July 15, 2023

This review explores the complex regulation of bone integrity by mechanical loading, sex hormones, and neural elements, emphasizing their integration across the lifespan. The paper examines how these ...

KEY FINDING: Bone loss after spinal cord injury (SCI) is not solely due to disuse, suggesting a role for neural regulation.

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Spinal Cord InjuryGeneticsMusculoskeletal Medicine

Spinal cord injury dysregulates fibro-adipogenic progenitors miRNAs signaling to promote neurogenic heterotopic ossifications

Communications Biology, 2023 • September 1, 2023

This study investigates the role of miRNAs in neurogenic heterotopic ossifications (NHOs) following spinal cord injury (SCI) using a mouse model and patient cells. It identifies an osteo-suppressive mi...

KEY FINDING: SCI induces mineralization and exacerbates osteo-chondrogenic markers expression in cardiotoxin (CDTX) damaged muscle.

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SurgeryOrthopedicsMusculoskeletal Medicine

Comparison of percutaneous vertebroplasty and conservative treatment for one level thoracolumbar osteoporotic compression fracture in a 3‑year study

Scientific Reports, 2023 • December 1, 2023

The study evaluated mesh-optimized PVP against traditional PVP for osteoporotic vertebral compression fractures, finding the optimized method superior. Mesh-optimized PVP demonstrated shorter operatio...

KEY FINDING: Mesh optimization group had improved operation time (34.8 ± 6.5 min) compared to traditional PVP group (42.7 ± 8.2) min.

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Cardiovascular ScienceOrthopedicsMusculoskeletal Medicine

Coagulation parameters correlate to venous thromboembolism occurrence during the perioperative period in patients with spinal fractures

Journal of Orthopaedic Surgery and Research, 2023 • November 25, 2023

This retrospective study investigated the correlation between coagulation parameters and VTE occurrence in patients with spinal fractures. It identified several risk factors, including age, spinal cor...

KEY FINDING: D-Dimer, FIB, and FDP levels were significantly elevated in VTE patients compared to non-VTE patients.

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NeurologySurgeryMusculoskeletal Medicine

Comparison of Posterior Approach and Combined Anterior-Posterior Approach in the Treatment of Ankylosing Spondylitis Combined With Cervical Spine Fracture: A Systematic Review and Meta-Analysis

Global Spine Journal, 2024 • May 1, 2024

This meta-analysis compared the posterior approach and combined anterior-posterior approach for treating ankylosing spondylitis (AS) patients with cervical spine fractures. The posterior approach was ...

KEY FINDING: The posterior approach resulted in significantly less intraoperative blood loss compared to the combined approach.

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