Coagulation parameters correlate to venous thromboembolism occurrence during the perioperative period in patients with spinal fractures

Venous thromboembolism (VTE) is a significant cause of mortality in hospitalized patients, especially after spinal injury surgery. This study aimed to identify coagulation-related parameters that could predict VTE occurrence in these patients. The study retrospectively analyzed patients with spinal fractures, looking at risk factors and coagulation parameters like D-dimer, fibrinogen (FIB), and fibrinogen degradation products (FDP) to see how they relate to VTE occurrence. The research found that elevated levels of D-dimer, FIB, and FDP, along with age over 60, spinal cord injury, and prolonged bed rest after surgery, were strong indicators of VTE risk.

• 1
  D-Dimer, FIB, and FDP levels were significantly elevated in VTE patients compared to non-VTE patients.
• 2
  Age ≥ 60, spinal cord injury, postoperative bedtime over 5 days, plasma D-dimer ≥ 0.54 mg/L, plasma fibrinogen ≥ 3.75 g/L and plasma FDP ≥ 5.19 mg/L were positively correlated to VTE.
• 3
  A joint model integrating D-Dimer, FIB, and FDP predicted VTE occurrence with higher accuracy (AUC of 0.88) compared to individual parameters.