Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 571-580 of 730 results
Chinese Journal of Reparative and Reconstructive Surgery, 2024 • February 1, 2024
This study investigates the effect of M2 microglia (M2-MG) transplantation on spinal cord injury (SCI) repair in mice. The results showed that M2-MG transplantation improves the motor function of the ...
KEY FINDING: M2-MG promoted axon growth when co-cultured with DRGs in vitro.
Front. Immunol., 2024 • February 20, 2024
This study investigated the therapeutic potential of macrophage secretomes for spinal cord injury (SCI) recovery, focusing on the differential effects of secretomes from macrophages with varying polar...
KEY FINDING: Secretome from M(IL-10+TGF-b1) macrophages significantly promoted axonal regeneration in vitro and functional recovery in a mouse model of SCI.
Neural Regeneration Research, 2024 • January 31, 2024
This study demonstrates that RUX promotes functional recovery after SCI by enhancing motor function and axon regeneration. RUX restores the expression of EAAT2 in astrocytes, reduces inflammation, and...
KEY FINDING: Ruxolitinib promotes motor function recovery and neuronal survival after spinal cord injury in mice.
Tissue Eng Regen Med, 2024 • March 26, 2024
This editorial discusses immunomodulation strategies to enhance nerve recovery after spinal cord injury (SCI). Various therapeutic methods, including stem cell transplantation, cytokine delivery, and ...
KEY FINDING: Stem cells like MSCs and NSCs can release anti-inflammatory cytokines and reduce the migration of inflammatory cells to the injured area, promoting recovery from spinal cord damage.
Journal of Neuroinflammation, 2024 • April 2, 2024
This study investigates the role of microglia and Fascin-1 in regulating the mechanical properties of the injured spinal cord following a crush injury in mice. The researchers found that spinal cord t...
KEY FINDING: Spinal cord tissue softens after crush injury, and microglia migration may be involved in the glial scar-mediated spinal cord softening after SCI.
Cells, 2024 • March 26, 2024
The study of NF-κB and JAK/STAT pathways in the context of SCI reveals a complex network of signaling events crucial for understanding neuroinflammation and glial dynamics. NF-κB’s role extends beyond...
KEY FINDING: NF-κB and STAT3 are transcription factors that play a pivotal role in initiating gene expression related to astrogliosis.
Nanomaterials, 2024 • April 22, 2024
This review explores the potential of α-gal nanoparticles to induce regeneration in adult mice, mimicking the natural regenerative abilities observed in amphibians. The approach focuses on activating ...
KEY FINDING: α-Gal nanoparticles induce rapid and extensive macrophage recruitment in adult mice injuries.
Cell Genomics, 2024 • May 8, 2024
Single-cell RNA sequencing (scRNA-seq) and T cell receptor sequencing (TCR-seq) are pivotal for investigating T cell heterogeneity. Herein, we present UniTCR, a novel low-resource-aware multimodal rep...
KEY FINDING: UniTCR enables detailed single-modality analysis by incorporating information from the other modality, offering a detailed understanding beyond what conventional single-modality approaches provide.
Front. Bioeng. Biotechnol., 2024 • April 19, 2024
This study introduces P-RuFe, a metal-organic framework activated by X-rays, exhibiting neurogenic and neuroprotective properties to repair traumatic SCI by improving the post-injury microenvironment....
KEY FINDING: The combined strategy (P-RuFe and X-ray) reduces immune cell infiltration, correlating with decreased tissue degeneration after SCI.
bioRxiv, 2024 • April 24, 2024
This study investigates the role of sustained neuroinflammation in chronic spinal cord injury (SCI) and its impact on axon regeneration. The researchers used PLX-5622 to deplete macrophages/microglia ...
KEY FINDING: Macrophages and microglia repopulate the chronically injured spinal cord after depletion with PLX-5622, returning to pre-depleted levels, suggesting a homeostatic mechanism.