Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 581-590 of 730 results
Neurotherapeutics, 2024 • May 1, 2024
This study investigated the effects of selective PDE4B and PDE4D inhibitors on SCI pathology in mice. The PDE4D inhibitor Gebr32a improved functional and histopathological outcomes after SCI, similar ...
KEY FINDING: The PDE4D inhibitor Gebr32a improved functional recovery after SCI, even when administered 2 days post-injury.
Frontiers in Immunology, 2024 • June 11, 2024
This commentary provides additional considerations regarding the feasibility, efficacy, and safety of xenogeneic ovine bone marrow mesenchymal stem cells transplantation in SCI. The authors' research d...
KEY FINDING: Xenogeneic sheep bone marrow MSCs can engraft at the injury site in a rat SCI model.
Journal of Nanobiotechnology, 2024 • May 28, 2024
This study introduces a nanoenzyme-based scaffold (NS@COP) designed to address key challenges in spinal cord injury (SCI) repair, including inflammation, mitochondrial dysfunction, and glial scar form...
KEY FINDING: NS@COP restores the responsiveness of pro-inflammatory macrophages to CGRP by upregulating RAMP1, promoting an anti-inflammatory M2 phenotype.
Frontiers in Immunology, 2024 • July 4, 2024
This study demonstrates that MVP is markedly increased in PAAD tissues and correlated with an adverse prognosis. Related analyses confirmed its potential as a novel diagnostic and prognostic indicator...
KEY FINDING: MVP is abnormally upregulated in PAAD tissues and correlates with adverse prognosis.
Journal of Neuroinflammation, 2024 • January 1, 2024
This study investigates the role of lactate-derived histone lactylation in spinal cord injury (SCI) repair, revealing that lactate levels and lactylation, particularly H4K12la, are upregulated in micr...
KEY FINDING: Lactate levels and lactylation are upregulated in the spinal cord, particularly in microglia, after SCI.
Frontiers in Pharmacology, 2024 • August 13, 2024
The study introduces Mn-doped ZIF nanozymes as a novel approach to tumor therapy. These nanozymes leverage the high H2O2 concentration in tumor microenvironments to generate hydroxyl radicals, directl...
KEY FINDING: Mn-ZIF nanozymes possess peroxidase (POD) activity, enabling them to oxidize tumor-localized H2O2 into hydroxyl radicals (·OH), effectively killing tumor cells.
Cell Communication and Signaling, 2024 • August 6, 2024
This study confirms a myeloproliferative role of NLRP3 by demonstrating that the expression of NLRP3 and the NLRP3 inflammasome-related genes ASC, IL1B, and IL18 is increased in AML patient cells comp...
KEY FINDING: Elevated NLRP3 expression is associated with diminished overall survival in AML patients, suggesting a critical role in AML pathogenesis.
Frontiers in Cellular and Infection Microbiology, 2024 • October 7, 2024
This study investigates the function of PfNSUN1, an RNA m5C methyltransferase, in Plasmodium falciparum. It demonstrates that PfNSUN1 is indispensable for parasite growth and development during the in...
KEY FINDING: PfNSUN1 is required for parasite development during the intraerythrocytic developmental cycle (IDC). Knockdown of PfNSUN1 resulted in a significant decrease in parasite growth efficiency.
Journal of Nanobiotechnology, 2024 • October 9, 2024
This study designed and synthesized curcumin nanoparticles (HA-CurNPs) with excellent biocompatibility for effective treatment of SCI. HA-CurNPs exhibit better antioxidant performance compared to both...
KEY FINDING: HA-CurNPs effectively protect neuronal cells and myelin, reduce glial scar formation, thereby facilitating the repair of damaged spinal cord tissues, restoring electrical signaling at the injury site, and improving motor functions.
The Journal of Neuroscience, 2025 • January 1, 2025
This study investigates the role of nonresolving neuroinflammation in regulating axon regeneration in chronic spinal cord injury (SCI). The researchers used PLX-5622 to deplete microglia and macrophag...
KEY FINDING: Macrophages and microglia repopulate the chronically injured spinal cord after depletion, indicating a homeostatic mechanism maintaining their presence.