Enhancing anti-neuroinﬂammation effect of X-ray-triggered RuFe-based metal-organic framework with dual enzyme-like activities

Front. Bioeng. Biotechnol., 2024 · DOI: 10.3389/fbioe.2024.1269262 · Published: April 19, 2024

Spinal Cord Injury Immunology Biomedical

Simple Explanation

Traumatic spinal cord injury (SCI) leads to paralysis and presents clinical challenges. Current treatments have limited efficacy and side effects. This study developed an X-ray-triggered nanoplatform (P-RuFe) for SCI recovery. The P-RuFe platform mimics enzyme activities to reduce reactive oxygen species and protect cells from oxidative stress. In mouse studies, P-RuFe with X-ray treatment reduced mortality and promoted spinal cord repair by inhibiting glial cell proliferation and neuroinflammation. P-RuFe shows potential as a safe and effective scavenger of reactive oxygen and nitrogen species, with good stability, biocompatibility, and high catalytic activity, offering promise for treating inflammation-related diseases.

Study Duration

Not specified

Participants

SCI mouse models

Evidence Level

Not specified

Key Findings

1
The combined strategy (P-RuFe and X-ray) reduces immune cell infiltration, correlating with decreased tissue degeneration after SCI.
2
The combined strategy fosters a proregenerative microenvironment, characterized by immune cell phenotypes, increased axons and myelination, and improved functional recovery.
3
P-RuFe, when combined with X-ray irradiation, can effectively promote the repair of damaged neurons, offering a promising avenue for in vivo treatment of spinal cord injuries.

Research Summary

This study introduces P-RuFe, a metal-organic framework activated by X-rays, exhibiting neurogenic and neuroprotective properties to repair traumatic SCI by improving the post-injury microenvironment. Upon X-ray stimulation, P-RuFe is rapidly taken up by macrophages within lysosomes, reducing RONS levels. In vivo, a single X-ray irradiation with P-RuFe significantly enhances motor neuron axon growth in traumatic SCI mice, improving motor function rehabilitation. The effectiveness of P-RuFe stems from its multifaceted ability to attenuate inflammatory responses and target inflammatory macrophages, showing potential in nerve repair and neurological research.

Practical Implications

Therapeutic Potential for SCI

The P-RuFe nanoplatform offers a new approach to treat spinal cord injuries by promoting nerve regeneration and reducing neuroinflammation.

Enhanced Radiotherapy

The use of high-Z elements in nanozymes can augment radiation-induced therapeutic efficacy, improving anti-inflammatory effects.

Applications in Neurological Research

The study's findings highlight the potential of P-RuFe in broader applications within neurological research and tissue engineering.

Study Limitations

1
The absorption of high radiation doses by healthy tissues often results in inevitable damage to normal skin and organs.
2
A persistently high concentration of hydrogen peroxide (H2O2) remains a challenge.
3
Further studies are needed to fully elucidate the long-term effects and optimal dosages of P-RuFe in SCI treatment.

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