Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 561-570 of 730 results
Bioactive Materials, 2024 • January 1, 2024
This study introduces an innovative approach to treating spinal cord injury (SCI) by transplanting engineered mitochondrial compounds that target macrophages. The engineered Mito-Tpp-CAQK compound enh...
KEY FINDING: Engineered mitochondrial compounds (Mito-Tpp-CAQK) significantly enhanced macrophage phagocytosis of myelin debris both in vitro and in vivo.
Not specified, 2023 • October 31, 2023
The study identifies novel populations of bone marrow-derived myeloid cells with neuroprotective and pro-regenerative properties, generated through short-term culture with IL-4 and G-CSF. These IL-4/G...
KEY FINDING: IL-4/G-CSF polarization reprograms bone marrow neutrophils (BMNs), causing them to upregulate alternative activation markers and produce cytoprotective and growth factors, akin to zymosan-modulated counterparts.
BMC Infectious Diseases, 2023 • November 14, 2023
This study aimed to determine the rate of post-COVID-19 syndrome (PCS) among SARS-CoV-2 seropositive blood donors and to investigate the role of Epstein-Barr virus (EBV) reactivation in PCS. The resul...
KEY FINDING: 18% of individuals with asymptomatic or mild SARS-CoV-2 infections experienced PCS symptoms lasting up to one year.
Clinical and Translational Medicine, 2023 • November 6, 2023
The emergence of antimalarial drug resistance poses a significant obstacle to effective malaria treatment and control, especially in sub-Saharan Africa. The Horn of Africa is a new hotspot for artemis...
KEY FINDING: Artemisinin-resistant malaria is increasing in the Horn of Africa and is coupled with the spread of parasites undetectable by standard rapid diagnostic tests.
Int. J. Mol. Sci., 2023 • November 7, 2023
Mesenchymal stem cells (MSCs) modulate immune responses and maintain self-tolerance, making them potential immunosuppressants for treating autoimmune and autoinflammatory diseases. An increased unders...
KEY FINDING: MSCs are passive targets in inflammatory conditions, becoming impaired and losing their immunomodulatory function.
Advanced Science, 2024 • November 30, 2023
The study demonstrates that DsEVs can act as carriers for APL MBP87-99A91 (A91-DsEVs) to induce the activation of 2 helper T (Th2) and regulatory T (Treg) cells for spinal cord injury (SCI) in mice. T...
KEY FINDING: DsEVs carrying APL MBP87-99A91 (A91-DsEVs) can activate specific types of CD4+ T cells (Th2 and Treg) in mice with SCI.
Materials Today Bio, 2023 • November 10, 2023
This study introduces a novel biomimetic nanoplatform, pCel, for treating spinal cord injury (SCI) by leveraging the anti-inflammatory and neuroprotective properties of celastrol. In vitro and in vivo...
KEY FINDING: The pCel nanoplatform exhibits high ROS scavenging activity and promotes the polarization of M1 macrophages toward the M2 phenotype in vitro.
Neural Regen Res, 2024 • August 1, 2024
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammatory reactions. Neur...
KEY FINDING: NETs are key mediators of inflammation and thrombosis, and have been widely accepted as a mechanism of deep vein thrombosis.
Current Osteoporosis Reports, 2024 • January 10, 2024
OSM plays unique roles in regulating the maintenance and regeneration of bone, hematopoietic stem and progenitor cells, inflammation, and skeletal muscles. Dysregulated OSM production can lead to bone...
KEY FINDING: OSM regulates bone mass by stimulating osteoclast formation and promoting osteoblast commitment through the OSMR receptor.
Diagnostics, 2024 • January 9, 2024
IL-10 regulates inflammation, oxidative stress, neuronal apoptosis, and glial scars after an SCI, and its neuroprotective properties have been shown in animal studies. IL-10 administration, alone or w...
KEY FINDING: IL-10 suppresses pro-inflammatory cytokines like TNF-α, IL-1β, IL-6, and IL-12, which improves functional recovery after traumatic SCIs.