Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 281-290 of 730 results
Cell & Bioscience, 2025 • January 23, 2025
This study demonstrates that trehalose enhances myelin debris clearance and reduces foamy macrophage formation after SCI by inducing TFEB expression in macrophages and modulating the autophagy-lysosom...
KEY FINDING: Trehalose enhances macrophage phagocytosis and clearance of myelin debris in a dose-dependent manner in vitro, with an optimal concentration of 20 mM.
Frontiers in Immunology, 2025 • January 15, 2025
This study demonstrates that low-level spinal cord injury (SCI) enhances lung inflammation and immune responses in mice exposed to lipopolysaccharide (LPS), mimicking a bacterial infection. SCI amplif...
KEY FINDING: Spinal cord injury (SCI) at the T9 level amplifies lung inflammation in mice following exposure to lipopolysaccharide (LPS), as evidenced by increased pro-inflammatory gene expression and cytokine release.
Journal of Neuroinflammation, 2025 • January 27, 2025
This study demonstrates a significant upregulation of C/EBPβ in microglia in a mouse model of SCI, suggesting its involvement in the post-SCI neuroinflammatory response. The research uncovers that C/E...
KEY FINDING: C/EBPβ is significantly upregulated in microglia after spinal cord injury in mice and is associated with neuroinflammation.
Neurochemical Research, 2025 • January 16, 2025
This study investigates the mechanisms underlying neuropathic pain (NP), focusing on the role of mTOR in astrocytes. It finds that mTOR is activated in astrocytes following chronic constriction injury...
KEY FINDING: mTOR is activated in astrocytes within the spinal cord following chronic constriction injury (CCI), contributing to neuropathic pain.
Journal of Neuroinflammation, 2025 • February 14, 2025
This study investigates the microglial response from subacute to chronic cervical SCI in rats, finding distinct microglial signatures that overlap between the subacute and chronic periods. The subacut...
KEY FINDING: Subacute SCI is characterized by a disease-associated microglial (DAM) signature, while chronic SCI is highly heterogeneous, with both injury-induced and homeostatic states.
J. Clin. Med., 2025 • February 21, 2025
The study provides a current snapshot of the frequency of urinary incontinence (UI) and urinary tract infections (UTIs) in the spinal cord injury (SCI) population using data from the National Spinal C...
KEY FINDING: Approximately 40% reported UI in the past month and over 50% had a UTI requiring antibiotics in the past year.
Spinal Cord, 2021 • September 1, 2021
This study investigated the potential of uNGAL as a biomarker for UTI in adults with NLUTD, a population where diagnosing UTIs is challenging. The findings suggest that uNGAL levels are associated wit...
KEY FINDING: uNGAL levels varied significantly among adults with NLUTD, even without UTI symptoms.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
This retrospective chart review assessed the incidence of urinary tract infections (UTIs) among recent spinal cord injury (SCI) patients initiating intermittent catheterization (IC) at two European re...
KEY FINDING: The incidence of UTI within three months of initiating IC varied significantly depending on the definition used, ranging from 13.7% to 45.2%.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
This study compared circulating antibody levels in individuals with chronic SCI and uninjured controls, revealing significantly elevated IgA and IgG2 levels in the SCI group. Elevated IgA levels corre...
KEY FINDING: IgA levels were significantly elevated in participants with chronic SCI compared to uninjured participants (median: 1.98 vs. 1.21 mg/ml, P < 0.0001).
The Journal of Spinal Cord Medicine, 2022 • December 31, 2020
This case series describes the clinical features and disease course of COVID-19 in seven veterans with spinal cord injury (SCI) treated at a single center during the COVID-19 pandemic. The study found...
KEY FINDING: Level and completeness of SCI did not appear to correlate with COVID-19 severity.