Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 271-280 of 730 results
Journal of Orthopaedic Translation, 2024 • July 29, 2024
We found that PHI exerted anti- neuroinflammatory effects by inactivating the NF-κB signaling pathway by targeting TLR4. PHI can efficiently prevent microglial activation and the subsequent neuroinfla...
KEY FINDING: PHI significantly inhibited the inflammatory response and neuronal apoptosis while enhancing axonal regeneration and improving motor function recovery in vivo.
Healthcare, 2024 • September 9, 2024
This study investigated COVID-19 vaccination rates in the Ontario SCI/D population and identified the impact of various characteristics on vaccine uptake. The study found that over 80% of the communit...
KEY FINDING: Over 80% of the SCI/D population received full COVID-19 vaccine coverage within one year of vaccine availability.
J South Med Univ, 2024 • August 1, 2024
This study investigates the neuroprotective effects of Linarin (LIN) on spinal cord injury (SCI) in mice, focusing on its ability to mitigate microglia-mediated inflammation and neuronal apoptosis. Th...
KEY FINDING: Linarin treatment significantly improved motor function in SCI mice, as evidenced by higher BMS scores, better performance in the inclined plane test, and improved footprint analysis scores.
Journal of Neuroinflammation, 2024 • September 16, 2024
This study demonstrates that exercise training can mitigate motor deficits and pathological changes in a mouse model of Parkinson's disease (PD). The key mechanism involves exercise-induced upregulati...
KEY FINDING: Exercise training inhibits microglial activation and synaptic phagocytosis in the striatum of PD mice.
Int. J. Mol. Sci., 2024 • October 1, 2024
This study investigates the role of miR-19a and miR-19b in microglia activation and neuroinflammation using transcriptomic profiling of primary microglia. The results demonstrate that miR-19a and miR-...
KEY FINDING: miR-19a and miR-19b up- and downregulate different genes, leading to distinct inflammatory responses in microglia.
Porto Biomed. J., 2024 • June 1, 2024
The study characterized the microbiological profile of urine cultures in SCI patients and determined antibiotic susceptibility profiles. E. coli was the most common microorganism, with variations base...
KEY FINDING: E. coli was the most common microorganism found in both UTIs and UTCs.
Mædica - a Journal of Clinical Medicine, 2024 • July 13, 2024
This meta-analysis and systematic review aimed to estimate the pooled incidence of myocardial infarction (MI) after COVID-19 vaccination. The study found that the incidence of MI after COVID-19 vaccin...
KEY FINDING: The incidence of MI after COVID-19 vaccines was insignificant (0%, I2=99%, P<0.001).
Immunity, Inflammation and Disease, 2024 • November 13, 2024
This study investigates the role of Tim-3 in spinal cord ischemia-reperfusion injury (SCIRI) using a rat model and in vitro experiments. The aim is to explore potential therapeutic effects of a Tim-3 ...
KEY FINDING: Tim-3 is highly expressed in spinal cord tissues of SCIRI rats. Blocking Tim-3 attenuated SCIRI-induced pathological injury, neuronal apoptosis, neuroinflammation, and microglia activation (M1 polarization).
Front. Neurosci., 2024 • December 11, 2024
This study investigates the analgesic effects of Dahuang Fuzi Decoction (DF) on neuropathic pain (NeP) using a rat model of chronic sciatic nerve compression injury (CCI). The research combines chemic...
KEY FINDING: DF treatment significantly increased the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in CCI rats, indicating its analgesic effect.
Frontiers in Pharmacology, 2024 • December 12, 2024
The study investigates the molecular mechanisms of tomatidine in modulating the inflammatory response and promoting functional rehabilitation after SCI. Results show that tomatidine can alleviate neur...
KEY FINDING: Tomatidine promotes neuronal damage recovery and reduces histopathological changes in spinal cord tissues and LPS-induced PC-12 cells.