Elevated levels of IgA and IgG2 in individuals with chronic spinal cord injury

This study investigated the levels of different types of antibodies in individuals with chronic spinal cord injury (SCI) compared to those without SCI. Infections are a major cause of rehospitalization and death for individuals with SCI, highlighting the importance of understanding their immune responses. The researchers found that individuals with chronic SCI had significantly higher levels of IgA and IgG2 antibodies in their blood compared to uninjured individuals. IgA is commonly found at mucosal surfaces, which are frequent sites of infection in individuals with SCI. These findings suggest that the immune system in individuals with chronic SCI is altered, with potentially important implications for their susceptibility to infections and responses to emerging infectious diseases. Further research is needed to understand the role of these antibodies in SCI and their impact on health outcomes.

• 1
  IgA levels were significantly elevated in participants with chronic SCI compared to uninjured participants (median: 1.98 vs. 1.21 mg/ml, P < 0.0001).
• 2
  IgG2 antibodies were also significantly elevated in participants with SCI compared to uninjured participants (median: 5.98 vs. 4.37 mg/ml, P < 0.018).
• 3
  IgA levels were highest in participants with motor complete injuries compared to uninjured participants (P < 0.0003).