The association between urine neutrophil gelatinase-associated lipocalin and UTI in people with neurogenic lower urinary tract dysfunction

Spinal Cord, 2021 · DOI: 10.1038/s41393-020-00552-x · Published: September 1, 2021

Simple Explanation

People with NLUTD are prone to UTIs, but diagnosing these infections can be difficult. Standard UTI tests aren't accurate for those with NLUTD. uNGAL, a marker of kidney injury, may help identify UTIs in NLUTD patients. This study explores uNGAL levels in adults with NLUTD. The study examined the link between uNGAL levels and the likelihood of having a UTI in adults with NLUTD.

Study Duration

18 months

Participants

27 adults with neurogenic lower urinary tract dysfunction

Evidence Level

Not specified

Key Findings

1
uNGAL levels varied significantly among adults with NLUTD, even without UTI symptoms.
2
uNGAL levels were higher in people likely to have a UTI compared to those unlikely to have a UTI or with no UTI.
3
uNGAL is associated with clinical profiles of Likely UTI, suggesting its utility as a marker of UTI in people with NLUTD.

Research Summary

This study investigated the potential of uNGAL as a biomarker for UTI in adults with NLUTD, a population where diagnosing UTIs is challenging. The findings suggest that uNGAL levels are associated with the likelihood of having a UTI in this population, with higher levels observed in those with a clinical profile indicative of UTI. The study highlights the need for further research to understand the variations in uNGAL levels and their implications for clinical care in people with NLUTD.

Practical Implications

Improved UTI Diagnosis

uNGAL could help clinicians better diagnose UTIs in NLUTD patients, reducing unnecessary antibiotic use.

Personalized Treatment

Understanding uNGAL variations could lead to more tailored UTI management strategies for this population.

Future Research

Further studies are needed to refine uNGAL's role and establish clear clinical guidelines for its use in NLUTD care.

The association between urine neutrophil gelatinase-associated lipocalin and UTI in people with neurogenic lower urinary tract dysfunction

Simple Explanation

Key Findings

Research Summary

Practical Implications

Improved UTI Diagnosis

Personalized Treatment

Future Research

Study Limitations

Your Feedback

Was this summary helpful?

The association between urine neutrophil gelatinase-associated lipocalin and UTI in people with neurogenic lower urinary tract dysfunction

Simple Explanation

Key Findings

Research Summary

Practical Implications

Improved UTI Diagnosis

Personalized Treatment

Future Research

Study Limitations

Your Feedback

Was this summary helpful?