Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 141-150 of 730 results
Journal of Neuroinflammation, 2023 • July 5, 2023
This study investigates the role of iron-induced B cell pyroptosis in promoting inflammation after spinal cord injury (SCI). The researchers found that SCI damages spleen function, leading to a decrea...
KEY FINDING: Spinal cord injury (SCI) can damage spleen function and lead to a decrease in B cell levels.
BMC Veterinary Research, 2023 • July 12, 2023
The study investigated the long-term changes in Th17 and Treg cells in dogs with spinal cord injury (SCI) after intervertebral disc herniation (IVDH). The findings indicate that while Th17 and Treg ce...
KEY FINDING: Significantly higher levels of Th17 and Treg cells were detected after recovery from IVDH compared to the acute stage.
Neural Regeneration Research, 2024 • January 1, 2024
This study investigates the inhibitory effects of photobiomodulation (PBM) on the accumulation of chondroitin sulfate proteoglycans (CSPGs) after spinal cord injury (SCI). The findings demonstrate tha...
KEY FINDING: PBM irradiation markedly increased Basso Mouse Scale scores in SCI model mice from day 7 post-injury, and this difference was maintained until day 28.
Neural Regeneration Research, 2024 • February 1, 2024
This study investigates the therapeutic potential of argatroban, a thrombin inhibitor, in promoting recovery after spinal cord injury (SCI) in rats. The findings indicate that argatroban improves neur...
KEY FINDING: Argatroban effectively promoted neurological function recovery after spinal cord injury in rats.
Frontiers in Immunology, 2023 • July 11, 2023
This study investigates the role of microglial Ccl2 in neuropathic pain associated with chronic spinal compression. It identifies Ccl2 as a key gene upregulated in microglia after SCI and demonstrates...
KEY FINDING: Ccl2 was identified as the primary gene altered in microglia within a rat SCI model.
Pharmaceuticals, 2023 • July 19, 2023
This study evaluates the analgesic effects of mirogabalin in a mouse model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve. The results indicate that mirogabalin ...
KEY FINDING: A single dose of mirogabalin is more effective than pregabalin in reducing tactile hypersensitivity in mice with nerve injury.
Neurosci Lett, 2023 • September 25, 2023
This study investigates the effects of pramipexole and dexpramipexole on chronic allodynia and cytokine expression in mice with sciatic nerve damage. The researchers hypothesized that both compounds w...
KEY FINDING: Both pramipexole and dexpramipexole significantly reduced allodynia in mice within one hour of intravenous injection, although the effect was temporary, with allodynia returning after 24 hours.
Journal of Inflammation Research, 2023 • August 8, 2023
This study investigates the temporal and spatial changes in the expression of TNFα and IFNγ in the spinal cord and spleen following high thoracic SCI in rats to understand the development of autonomic...
KEY FINDING: Spleen weight decreases acutely at 3 days post-injury (DPI) and again after 8 weeks compared to naïve age-matched controls, indicating a biphasic atrophy pattern.
Cellular & Molecular Biology Letters, 2023 • September 7, 2023
This study investigates the role of astrocyte senescence in neuroinflammation and neuropathic pain (NeP) following peripheral nerve injury (PNI). The findings suggest that PNI induces a senescence-lik...
KEY FINDING: Sciatic nerve CCI in rats resulted in reduced paw mechanical withdrawal threshold (PMWT) and paw thermal withdrawal latency (PTWL), indicating pain hypersensitivity.
Cureus, 2023 • August 14, 2023
This case report presents a complex scenario involving a patient with spina bifida, diabetes, obesity, and osteomyelitis, investigating the interplay of these conditions. The study highlights the pivo...
KEY FINDING: The patient had a nonhealing sacral ulcer for one year, complicated by osteomyelitis, despite previous wound care management and antibiotic treatment.