Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 131-140 of 730 results
Int. J. Mol. Sci., 2023 • May 12, 2023
This study investigated the role of LCN2 in NLRP3 inflammasome-dependent neuroinflammation following spinal cord injury (SCI) using Lcn2−/− mice. The findings demonstrate that LCN2 enhances inflammato...
KEY FINDING: Significant activation of the HMGB1/PYCARD/caspase-1 inflammatory axis was observed 7 days after SCI in WT mice, accompanied by LCN2 overexpression.
Pathogens, 2023 • May 5, 2023
Histoplasmosis can involve the Central Nervous System (CNS) and is caused by Histoplasma capsulatum complex species. Once in the CNS, this pathogen causes life-threatening injuries that are associated...
KEY FINDING: CNS histoplasmosis, while less frequent than other forms, is associated with high mortality rates, even with aggressive treatments.
Frontiers in Molecular Neuroscience, 2023 • May 12, 2023
The study aimed to observe the effect of antagonizing the binding of Substance-P (SP) to its neurokinin-1 (NK1) receptor in a rodent SCI model using a neurokinin-1 receptor antagonist (NRA). Results s...
KEY FINDING: Blocking NK1R with EUC-001 reduced the invasion of T-lymphocytes and the number of apoptotic cells in the injured spinal cord.
Clinical Infectious Diseases, 2023 • June 3, 2023
This study evaluated the outcomes of customized phage therapy for 12 patients with difficult-to-treat antimicrobial-resistant infections. The customized phages were generated for 12 patients. After tr...
KEY FINDING: 42% (5/12) of cases showed bacterial eradication after treatment.
Arch Med Sci, 2023 • May 1, 2023
The study investigates the protective effect of tabersonine against spinal cord injury (SCI) in rats. SCI leads to multiple organ dysfunction and loss of motor and sensory function. The researchers ev...
KEY FINDING: Tabersonine treatment improved neurological and motor functions in spinal cord injured rats, as indicated by higher Tarlov scale and BBB scores compared to the SCI group.
PLOS ONE, 2023 • June 22, 2023
This study evaluated the effects of oral MaR1 treatment on neuropathic pain (NP) and spinal neuroinflammation in mice with spared nerve injury (SNI). MaR1 reduced mechanical hypersensitivity, potentia...
KEY FINDING: Oral MaR1 treatment reduced SNI-induced mechanical hypersensitivity in both male and female mice on days 7 and 11 post-surgery.
Biomedicines, 2023 • May 26, 2023
The study evaluated the anti-neuropathic activity of COR167, a novel selective CB2 agonist, in a preclinical model of peripheral neuropathy (SNI). Oral administration of COR167 reduced neuropathic pai...
KEY FINDING: Oral COR167 attenuated mechanical allodynia and thermal hyperalgesia in a dose-dependent manner after acute and repeated administration, without tolerance induction.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023 • March 24, 2023
This study aimed to investigate the effect of FGF23 on neuronal apoptosis, inflammation and locomotion recovery, as well as its underlying mechanism in experimental SCI models. In SCI model rats, FGF2...
KEY FINDING: FGF23 overexpression decreased cell apoptosis and inflammation in H2O2-stimulated neurons by activating the PI3K/AKT signaling pathway.
Journal of Neuroinflammation, 2023 • July 1, 2023
This study investigates the role of endothelial progenitor cell-derived exosomes (EPC-EXOs) in macrophage polarization following spinal cord injury (SCI) and explores the underlying mechanisms. The re...
KEY FINDING: EPC-EXOs decreased pro-inflammatory macrophage markers and increased anti-inflammatory markers after SCI.
Medicine, 2023 • July 7, 2023
This case report details a rare instance of hematomyelia (spinal cord hemorrhage) in a 40-year-old male with COVID-19. The patient presented with fever, urinary/fecal retention, and lower extremity pa...
KEY FINDING: This case report is the first to document hematomyelia, or spinal cord hemorrhage, associated with COVID-19 infection.