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  4. Hematomyelia associated with coronavirus disease 2019: A rare case report

Hematomyelia associated with coronavirus disease 2019: A rare case report

Medicine, 2023 · DOI: http://dx.doi.org/10.1097/MD.0000000000034197 · Published: July 7, 2023

ImmunologyNeurologyResearch Methodology & Design

Simple Explanation

COVID-19 can affect the central nervous system, potentially leading to conditions like cerebral hemorrhage. This case report presents a unique instance of hematomyelia, or spinal cord hemorrhage, associated with COVID-19, which has not been previously reported. A 40-year-old male, positive for COVID-19, experienced symptoms including fever, urinary and fecal retention, and lower extremity pain. MRI scans revealed a spinal cord hematoma and edema, with COVID-19 nucleic acid detected in his cerebrospinal fluid. The patient received anti-infection and immunomodulatory treatments, leading to significant symptom improvement and absorption of the spinal cord hematoma. This suggests these therapies may be effective in treating COVID-19-related hematomyelia.

Study Duration
Not specified
Participants
One 40-year-old male
Evidence Level
Level 4; Case Report

Key Findings

  • 1
    This case report is the first to document hematomyelia, or spinal cord hemorrhage, associated with COVID-19 infection.
  • 2
    Thoracic and lumbar MRI revealed subdural hematoma and spinal cord edema, confirmed through contrast-enhanced imaging and CSF analysis positive for COVID-19 nucleic acid.
  • 3
    Anti-infective and immunomodulatory therapies led to the absorption of the spinal cord hematoma and significant improvement in the patient's symptoms.

Research Summary

This case report details a rare instance of hematomyelia (spinal cord hemorrhage) in a 40-year-old male with COVID-19. The patient presented with fever, urinary/fecal retention, and lower extremity pain. Diagnosis was confirmed via MRI, revealing subdural hematoma and spinal cord edema, along with a positive COVID-19 nucleic acid test in the cerebrospinal fluid. Treatment involved anti-infection and immunomodulatory therapies, resulting in significant clinical improvement and hematoma absorption. This suggests potential therapeutic strategies for COVID-19-related spinal cord complications.

Practical Implications

Increased Awareness

Clinicians should consider spinal cord injury and hemorrhage in COVID-19 patients presenting with neurological symptoms.

Early Diagnosis

Prompt MRI and lumbar puncture are crucial for diagnosing spinal cord complications in COVID-19 patients.

Potential Therapies

Anti-infective and immunomodulatory therapies may be effective in treating COVID-19-related hematomyelia.

Study Limitations

  • 1
    Single case report limits generalizability.
  • 2
    Further research is needed to confirm the efficacy of anti-infective and immunomodulatory therapies.
  • 3
    The exact pathogenic mechanisms of COVID-19-related spinal cord injury remain unclear.

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