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  4. Spinal Cord Sarcoidosis Occurring at Sites of Spondylotic Stenosis, Mimicking Spondylotic Myelopathy: A Case Series and Review of the Literature

Spinal Cord Sarcoidosis Occurring at Sites of Spondylotic Stenosis, Mimicking Spondylotic Myelopathy: A Case Series and Review of the Literature

AJNR Am J Neuroradiol, 2023 · DOI: http://dx.doi.org/10.3174/ajnr.A7724 · Published: January 1, 2023

ImmunologyNeurologyMedical Imaging

Simple Explanation

Sarcoidosis is a disease that can affect many parts of the body, sometimes including the spinal cord. This can cause symptoms similar to those caused by spinal stenosis, a narrowing of the spinal canal. This study looks at five patients who had sarcoidosis of the spinal cord at the same location as spinal stenosis. The symptoms and appearance on imaging were very similar to those of spinal stenosis alone. The authors suggest that if a patient has spinal stenosis with unusual spinal cord findings on imaging, doctors should consider sarcoidosis as a possible cause, and investigate with chest imaging and possibly a lymph node biopsy.

Study Duration
2018 to 2019
Participants
5 patients with intramedullary spinal neurosarcoidosis
Evidence Level
Level 4: Case Series and Literature Review

Key Findings

  • 1
    Intramedullary spinal neurosarcoidosis can mimic spondylotic myelopathy both clinically and on imaging.
  • 2
    Intramedullary spinal neurosarcoidosis can occur in isolation at sites of spondylotic spinal canal stenosis.
  • 3
    In patients with cord enhancement at or just below a site of spinal canal stenosis, chest imaging and lymph node biopsy should be considered to assess for underlying sarcoidosis.

Research Summary

This case series describes 5 patients with intramedullary spinal neurosarcoidosis occurring at sites of spondylotic spinal canal stenosis. The clinical presentations and imaging findings can be indistinguishable from spondylotic myelopathy, making diagnosis challenging. The authors recommend considering chest imaging and lymph node biopsy in patients with cord enhancement at or just below spinal canal stenosis to rule out sarcoidosis before surgical decompression.

Practical Implications

Diagnostic Awareness

Raise awareness among radiologists and clinicians about the possibility of spinal cord sarcoidosis mimicking spondylotic myelopathy.

Diagnostic Workup

Incorporate chest imaging and lymph node biopsy in the diagnostic workup of patients with spinal cord enhancement at sites of spinal canal stenosis.

Treatment Strategy

Consider a trial of corticosteroids before surgical decompression in patients with suspected spinal cord sarcoidosis.

Study Limitations

  • 1
    Small sample size (5 patients)
  • 2
    Retrospective study design
  • 3
    Lack of long-term follow-up data for all patients

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