Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 441-450 of 1,773 results
bioRxiv preprint, 2024 • February 18, 2024
The study investigates the short and long-term effects of mouse serum-derived sEVs on pain modulation. sEVs from both naïve control and SNI model donor mice were found to transiently increase basal me...
KEY FINDING: Mouse serum-derived sEVs transiently increased basal mechanical thresholds in recipient mice, an effect mediated by opioid signaling.
Cell Communication and Signaling, 2024 • December 11, 2024
This study investigates the role of UTX, an epigenetic regulator, in endothelial cells following spinal cord injury (SCI), focusing on its impact on neural stem cell (NSC) differentiation. The researc...
KEY FINDING: UTX knockout in spinal cord microvascular endothelial cells (SCMECs) enhances neurogenesis in a mouse model of spinal cord injury (SCI).
CNS Neuroscience & Therapeutics, 2024 • January 28, 2024
This study investigates the therapeutic potential of AKBA for spinal cord injury (SCI) in rats, focusing on its anti-inflammatory and antioxidant properties. The results demonstrate that AKBA can atte...
KEY FINDING: AKBA enhances antioxidant enzyme activity and reduces oxidative damage in rats with SCI, partly through the Nrf2/HO-1 signaling pathway.
Journal of Neurotrauma, 2024 • November 1, 2024
This study evaluated the beneficial effects of human Schwann-cell exosomes (hSC-Exos) in a severe model of penetrating ballistic-like brain injury (PBBI) in rats and investigate effects on multiple ou...
KEY FINDING: hSC-Exos treatment reduced the number of activated microglia 48 hours post-injury.
Frontiers in Cellular Neuroscience, 2024 • March 5, 2024
This study demonstrates that lasmiditan, a 5-HT1FR agonist, induces mitochondrial biogenesis (MB) in brain microvascular endothelial cells (mBMEC). Lasmiditan enhances endothelial cell function by inc...
KEY FINDING: Lasmiditan treatment increased the maximal oxygen consumption rate, mitochondrial proteins and mitochondrial density in mBMEC, indicative of MB induction.
Int. J. Mol. Sci., 2024 • March 1, 2024
The study examined the therapeutic effect of EPA on fibromyalgia pain and its cellular mechanisms in a mouse model, using intermittent cold stress to induce fibromyalgia. EPA administration reversed m...
KEY FINDING: EPA attenuated mechanical and thermal hyperalgesia in mice with fibromyalgia.
Int. J. Mol. Sci., 2024 • March 6, 2024
This study examines the dynamics of endogenous miR133b levels in a mouse model of cervical contusion injury, focusing on the lesion site, proximal and distal spinal cord segments, prefrontal cortex, a...
KEY FINDING: Spinal cord injury causes an initial increase followed by a sustained decrease in miR133b levels at the injury site.
PLoS ONE, 2024 • March 20, 2024
This study evaluated the therapeutic potential of maropitant in treating neuropathic pain in rats by assessing its effects on oxidative stress, endoplasmic reticulum stress, and neuroinflammation in t...
KEY FINDING: Maropitant inhibited nociception with an ID50 value of 4.1 mg/kg in a neuropathic pain model induced by chronic constriction injury (CCI).
J Cell Mol Med, 2024 • February 22, 2024
This research focused on identifying necroptosis-related differentially expressed genes (NRDEGs) in spinal cord injury (SCI) to find potential therapeutic and prognostic target genes. The study identi...
KEY FINDING: Combined analysis identified 15 co-expressed DEGs and NRGs, highlighting pathways associated with necroptosis and apoptosis.
Orthopaedic Surgery, 2024 • May 1, 2024
The study investigates the role of FTO-mediated HO-1 m6A modification in neurological recovery following spinal cord injury (SCI) in mice. FTO upregulation was found to ameliorate OGD-induced neuronal...
KEY FINDING: FTO overexpression improves neurological function and reduces neuronal apoptosis in SCI mice.